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Gaocai Li
Researcher at Huazhong University of Science and Technology
Publications - 42
Citations - 1043
Gaocai Li is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 20 publications receiving 231 citations.
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Journal ArticleDOI
Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo
Zhiwei Liao,Rongjin Luo,Gaocai Li,Yu Song,Shengfeng Zhan,Kangcheng Zhao,Wenbin Hua,Yukun Zhang,Xinghuo Wu,Cao Yang +9 more
TL;DR: This work is the first to demonstrate that MSC-exos could modulate ER stress-induced apoptosis during AGEs-associated IVD degeneration, and highlight the therapeutic effects of exosomes in preventing IDD progression.
Journal ArticleDOI
A novel photothermally controlled multifunctional scaffold for clinical treatment of osteosarcoma and tissue regeneration
Liang Ma,Xiaobo Feng,Hang Liang,Kun Wang,Yu Song,Lei Tan,Bingjin Wang,Rongjin Luo,Zhiwei Liao,Gaocai Li,Xiangmei Liu,Shuilin Wu,Cao Yang +12 more
TL;DR: A novel photothermally controlled multifunctional scaffold, which not only kills human osteosarcoma cells but also facilitates tissue regeneration, is a promising clinical tool for treating tissue injuries from an osteosARcoma resection.
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Acid‐sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration
Kangcheng Zhao,Ran An,Qian Xiang,Gaocai Li,Kun Wang,Yu Song,Zhiwei Liao,Shuai Li,Wenbin Hua,Xiaobo Feng,Xinghuo Wu,Yukun Zhang,Abhirup Das,Abhirup Das,Cao Yang +14 more
TL;DR: This study focused on the regulation of acid‐sensitive ion channels (ASICs) in relation to inflammation and the effect of NLRP3 on pyroptosis levels in NP cells under acidic conditions.
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Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo .
Saideng Lu,Yu Song,Rongjin Luo,Shuai Li,Gaocai Li,Kun Wang,Zhiwei Liao,Bingjin Wang,Wencan Ke,Qian Xiang,Chao Chen,Xinghuo Wu,Yukun Zhang,Li Ling,Cao Yang +14 more
TL;DR: In this article, the role of ferroptosis in the pathogenesis of intervertebral disc degeneration (IVDD) is investigated and the underlying regulatory mechanisms are determined.
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Berberine ameliorates oxidative stress-induced apoptosis by modulating ER stress and autophagy in human nucleus pulposus cells.
Rongjin Luo,Zhiwei Liao,Yu Song,Huipeng Yin,Shengfeng Zhan,Gaocai Li,Liang Ma,Saideng Lu,Kun Wang,Shuai Li,Yukun Zhang,Cao Yang +11 more
TL;DR: Results indicate that berberine could prevent oxidative stress-induced apoptosis by modulating ER stress and autophagy, thus offering a novel potential pharmacological treatment strategy for IVD degeneration.