Xinying Yang

TL;DR: It is discovered that feedback activation of leukemia inhibitory factor receptor (LIFR) signaling in breast cancer limits the response to HDAC inhibition, implicating combination inhibition of HDAC with JAK1 or BRD4 as potential therapies for breast cancer.

TL;DR: This study provided the first evidence revealing a non-metabolic function of PGAM1 in promoting cell migration, and gained new insights into the role of PG AM1 in cancer progression.

TL;DR: ABE fermentation wastewater is one promising substrate for BC production and showed small influence on the BC structure by comparison with the BC products obtained in traditional HS medium using field emission scanning electron microscope (FE‐SEM), Fourier transform infrared spectroscopy (FTIR) and X‐ray diffraction (XRD).

TL;DR: The identification of the potent pan-FGFR inhibitor (R)-21c is described, which provided nearly complete inhibition of tumor growth in NCI-H1581 (FGFR1-amplified) xenograft mice model at the dose of 10 mg/kg/qd via oral administration.

TL;DR: It is reported that the transcriptional factor c-Myc functions as a downstream effector to dictate the therapeutic response to c-Met inhibitors in c- Met-addicted cancer and derived resistance, offering a preclinical proof of concept for the application of c- myc-blocking agents as a tactic to thwart resistance to kinase inhibitors.