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Shuang Tang
Researcher at Chinese Academy of Sciences
Publications - 54
Citations - 2471
Shuang Tang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Herpes simplex virus & Virus. The author has an hindex of 21, co-authored 52 publications receiving 2214 citations. Previous affiliations of Shuang Tang include Center for Biologics Evaluation and Research & Academia Sinica.
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Journal ArticleDOI
Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth.
TL;DR: Analysis of miRNA array analyses for age-matched normal cervix and cervical cancer tissues and cloning and sequencing of a HPV16+ CaSki cell small RNA library indicate that downregulation ofmiR-143 and miR-145 and upregulation ofMiR-146a play a role in cervical carcinogenesis.
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The E7 Oncoprotein Is Translated from Spliced E6*I Transcripts in High-Risk Human Papillomavirus Type 16- or Type 18-Positive Cervical Cancer Cell Lines via Translation Reinitiation
TL;DR: Direct evidence is provided that the E6*I mRNAs of high-risk HPVs are responsible for E7 production, which was confirmed by transient transfection in 293 cells: E7 could be translated only from the E7 open reading frame (ORF) on E 6*I mRNA in a distance-dependent matter of upstream E6-I ORF by translation reinitiation.
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An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factor
TL;DR: It is hypothesize that miR-I may modulate the outcome of viral infection in the peripheral nervous system by functioning as a molecular switch for ICP34.5, a key viral neurovirulence factor.
Journal ArticleDOI
microRNAs are biomarkers of oncogenic human papillomavirus infections.
Xiaohong Wang,Hsu Kun Wang,Yang Li,Yang Li,Markus Hafner,Markus Hafner,Nilam Sanjib Banerjee,Shuang Tang,Daniel Briskin,Daniel Briskin,Craig Meyers,Louise T. Chow,Xing Xie,Thomas Tuschl,Thomas Tuschl,Zhi-Ming Zheng +15 more
TL;DR: It is reported in this study that oncogenic human papillomaviruses (HPVs) induce aberrant expression of many cellular miRNAs and that HPV18 infection produces no detectable viral miRNA.
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Novel less-abundant viral microRNAs encoded by herpes simplex virus 2 latency-associated transcript and their roles in regulating ICP34.5 and ICP0 mRNAs
TL;DR: The use of high-throughput sequencing technology is reported to identify two additional relatively less-abundant viral miRNAs, miR-II andMiR-III, encoded by HSV-2 LAT exon 2.5, which suggest that LAT sequences likely contribute to HSV latency and reactivation through tight control of these LAT-encoded mi RNAs and their viral targets.