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Xiwen Dai
Researcher at Shenyang Pharmaceutical University
Publications - 8
Citations - 109
Xiwen Dai is an academic researcher from Shenyang Pharmaceutical University. The author has contributed to research in topics: Xanthine oxidase & Xanthine oxidase inhibitor. The author has an hindex of 4, co-authored 8 publications receiving 55 citations.
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Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.
TL;DR: Compound 10c was a potent and promising uric acid-lowing agent for the treatment of hyperuricemia and the results showed that compound 10c (5 mg/kg) was able to significantly lower the serum uric acids level.
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Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.
TL;DR: The result demonstrated that compound 8u could effectively reduce serum uric acid levels at an oral dose of 5 mg/kg and could be a potential and efficacious agent in treatment of hyperuricemia with low toxicity.
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Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
TL;DR: The results suggested that compound 1h could effectively reduce serum uric acid levels at an oral dose of 10 mg/kg and could be a promising lead compound for the treatment of hyperuricemia and gout.
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Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation
TL;DR: In this paper, a number of 3]-4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones (3a-,3w) were newly designed by a bioisosteric replacement and hybrid strategy with the hope of obtaining novel and effective nonpurine XO inhibitors.
Journal ArticleDOI
Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.
Ming Sun,Jiaxing Zhao,Qing Mao,Chengda Yan,Bing Zhang,Yuwei Yang,Xiwen Dai,Jun Gao,Fengwei Lin,Yulin Duan,Tingjian Zhang,Shaojie Wang +11 more
TL;DR: In this paper, a series of 2-phenylpyrimidine derivatives with amino or hydroxy functional group were synthesized that presented excellent in vitro xanthine oxidase inhibitory potency.