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Xueli Zhang
Researcher at Chinese Academy of Sciences
Publications - 150
Citations - 5356
Xueli Zhang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Fermentation & Medicine. The author has an hindex of 33, co-authored 129 publications receiving 4152 citations. Previous affiliations of Xueli Zhang include Shanghai Jiao Tong University & University of Florida.
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Journal ArticleDOI
Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains of Escherichia coli C that produce succinate and malate.
Kaemwich Jantama,Mark John Haupt,Spyros A. Svoronos,Xueli Zhang,Jonathan C. Moore,Keelnatham T. Shanmugam,Lonnie O. Ingram +6 more
TL;DR: Derivatives of Escherichia coli C were engineered to produce primarily succinate or malate in mineral salts media using simple fermentations (anaerobic stirred batch with pH control) without the addition of plasmids or foreign genes by combination of gene deletions and metabolic evolution.
Journal ArticleDOI
Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli C
Kaemwich Jantama,Xueli Zhang,Jonathan C. Moore,Keelnatham T. Shanmugam,Spyros A. Svoronos,Lonnie O. Ingram +5 more
TL;DR: Derivatives of Escherichia coli C were previously described for succinate production by combining the deletion of genes that disrupt fermentation pathways for alternative products with growth‐based selection for increased ATP production to create a strain devoid of foreign DNA.
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Metabolic evolution of energy-conserving pathways for succinate production in Escherichia coli
Xueli Zhang,Kaemwich Jantama,Jonathan C. Moore,Laura R. Jarboe,Keelnatham T. Shanmugam,Lonnie O. Ingram +5 more
TL;DR: Results of deleting individual transport genes confirmed that GalP served as the dominant glucose transporter in evolved strains and increased the pool of PEP available for redox balance by eliminating the need to produce additional PEP from pyruvate.
Journal ArticleDOI
Engineering central metabolic modules of Escherichia coli for improving β-carotene production
Jing Zhao,Qingyan Li,Tao Sun,Tao Sun,Xinna Zhu,Hongtao Xu,Jinlei Tang,Jinlei Tang,Xueli Zhang,Yanhe Ma +9 more
TL;DR: Combined engineering of TCA and PPP modules had a synergistic effect on improving β-carotene yield, leading to 64% increase of β-vehicle yield over a high producing parental strain.
Journal ArticleDOI
Glycosylase base editors enable C-to-A and C-to-G base changes.
Dongdong Zhao,Ju Li,Siwei Li,Xiuqing Xin,Xiuqing Xin,Muzi Hu,Muzi Hu,Marcus A. Price,Susan J. Rosser,Changhao Bi,Xueli Zhang +10 more
TL;DR: APOBEC-nCas9-Ung supplements the current adenine and cytidine BEs (ABE and CBE) and could be used to target G/C disease-causing mutations.