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Xueliang Du
Researcher at Albert Einstein College of Medicine
Publications - 27
Citations - 7836
Xueliang Du is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Diabetes mellitus & Insulin. The author has an hindex of 18, co-authored 23 publications receiving 7418 citations. Previous affiliations of Xueliang Du include Yeshiva University.
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Journal ArticleDOI
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
TL;DR: It is proposed that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism, which triggers a transient decrease in basal glucose levels in mice treated with streptozotocin.
Journal ArticleDOI
Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin IMPLICATIONS FOR METABOLIC REGULATION AND BIOACTIVITY
Utpal B. Pajvani,Xueliang Du,Terry P. Combs,Anders H. Berg,Michael W. Rajala,Therese Schulthess,Jürgen Engel,Michael Brownlee,Philipp E. Scherer +8 more
TL;DR: It is shown that there is a profound sexual dimorphism of Acrp30 levels and complex distribution in serum and a new model for in vivo activation of the protein, implicating a serum reductase activity is suggested.
Journal ArticleDOI
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
Xueliang Du,Takeshi Matsumura,Diane Edelstein,Luciano Rossetti,Zsuzsanna K. Zsengellér,Csaba Szabó,Michael Brownlee +6 more
TL;DR: It is shown that hyperglycemia-induced overproduction of superoxide by the mitochondrial electron transport chain activates the three major pathways of hyperglycemic damage found in aortic endothelial cells by inhibiting GAPDH activity.
Journal ArticleDOI
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
Hans-Peter Hammes,Xueliang Du,Diane Edelstein,Tetsuya Taguchi,Takeshi Matsumura,Qida Ju,Jihong Lin,Angelika Bierhaus,Peter P. Nawroth,Dieter Hannak,Michael Neumaier,Regine Bergfeld,Ida Giardino,Michael Brownlee +13 more
TL;DR: In this article, the lipid-soluble thiamine derivative benfotiamine can inhibit three major biochemical pathways simultaneously, which might be clinically useful in preventing the development and progression of diabetic complications.
Journal ArticleDOI
Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice
Richard W. Gelling,Xueliang Du,Darwin S. Dichmann,John Rømer,H. Huang,Lingguang Cui,Silvana Obici,B. Tang,Jens J. Holst,Christian Fledelius,Peter B. Johansen,Luciano Rossetti,Linda A. Jelicks,Palle Serup,Erica Nishimura,Maureen J. Charron +15 more
TL;DR: The data indicate that glucagon is essential for maintenance of normal glycemia and postnatal regulation of islet and α and δ cell numbers and the lean phenotype of Gcgr−/− mice suggests glucagon action may be involved in the regulation of whole body composition.