J
Jun Cai
Researcher at University of Louisville
Publications - 71
Citations - 3421
Jun Cai is an academic researcher from University of Louisville. The author has contributed to research in topics: Oligodendrocyte & OLIG2. The author has an hindex of 29, co-authored 65 publications receiving 2939 citations. Previous affiliations of Jun Cai include Wenzhou Medical College & Jilin University.
Papers
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Journal ArticleDOI
Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor.
Yingchuan Qi,Jun Cai,Yuanyuan Wu,Rui Wu,Jeffrey S. Lee,Hui Fu,Mahendra S. Rao,Lori Sussel,John L.R. Rubenstein,Mengsheng Qiu +9 more
TL;DR: The results strongly suggest that Nkx2.2 regulates the differentiation and/or maturation, but not the initial specification, of oligodendrocyte progenitors, and that overproduction of Nk X.2 protein in fibroblast cells can induce gene expression from the proteolipid protein promoter.
Journal ArticleDOI
Generation of Oligodendrocyte Precursor Cells from Mouse Dorsal Spinal Cord Independent of Nkx6 Regulation and Shh Signaling
Jun Cai,Yingchuan Qi,Xuemei Hu,Min Tan,Zijing Liu,Jianshe Zhang,Qun Li,Maike Sander,Mengsheng Qiu +8 more
TL;DR: In this study, in vivo evidence for a late phase of Olig gene expression independent of Nkx6 and Shh gene activities is provided and a brief second wave of oligodendrogenesis in the dorsal spinal cord is revealed.
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Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation.
Hui Fu,Yingchuan Qi,Min Tan,Jun Cai,Hirohide Takebayashi,Masato Nakafuku,William D. Richardson,Mengsheng Qiu +7 more
TL;DR: The co-expression of Nkx2.2 and Olig2 in OLPs is tightly associated with myelin gene expression in the normal and PDGFA(-/-) embryos, suggesting a cooperative role of these transcription factors in the control of oligodendrocyte differentiation.
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Current approaches to enhance CNS delivery of drugs across the brain barriers.
TL;DR: The current approaches to open or facilitate penetration across brain barriers for enhanced drug delivery to the CNS are reviewed, and the associated mechanisms and problems are discussed.
Journal ArticleDOI
Induction of oligodendrocyte differentiation by Olig2 and Sox10 : Evidence for reciprocal interactions and dosage-dependent mechanisms
TL;DR: Evidence is presented that the control of oligodendrocyte differentiation by Olig2, Sox10 and Nkx2.2 is a dosage-dependent developmental process and can be affected by both haploinsufficiency and over-dosage.