Showing papers by "Xueyuan Chen published in 2013"
TL;DR: A comprehensive survey of the latest advances made in developing lanthanide-doped inorganic nanoparticles as potential luminescent bioprobes covering areas from their fundamental chemical and physical features to bioapplications including controlled synthesis methodology, surface modification chemistry, optical spectroscopy, and their promising applications in diverse fields are provided.
Abstract: Lanthanide-doped inorganic nanoparticles possess superior physicochemical features such as long-lived luminescence, large antenna-generated Stokes or anti-Stokes shifts, narrow emission bands, high resistance to photobleaching and low toxicity, and thus are regarded as a new generation of luminescent bioprobes as compared to conventional molecular probes like organic dyes and lanthanide chelates. These functional nanoparticles, although most of their bulk counterparts were well studied previously, have attracted renewed interest for their biomedical applications in areas as diverse as biodetection, bioimaging, and disease diagnosis and therapeutics. In this review, we provide a comprehensive survey of the latest advances made in developing lanthanide-doped inorganic nanoparticles as potential luminescent bioprobes, which covers areas from their fundamental chemical and physical features to bioapplications including controlled synthesis methodology, surface modification chemistry, optical spectroscopy, and their promising applications in diverse fields, with an emphasis on heterogeneous and homogeneous in vitro biodetection of tumor markers and multimodal bioimaging of various tumor tissues. Some future prospects and challenges in this rapidly growing field are also summarized.
738 citations
222 citations
TL;DR: Lanthanide-doped luminescent nanoparticles have provoked considerable interest due to their superior features, such as sharp f–f emission peaks, a long photoluminescence lifetime, low toxicity, and high resistance to photo-bleaching.
Abstract: Lanthanide-doped luminescent nanoparticles (NPs) haveevoked considerable interest due to their superior features,such as sharp f–f emission peaks, a long photoluminescence(PL) lifetime, low toxicity, and high resistance to photo-bleaching, which make them extremely suitable for use asalternatives to organic fluorescent dyes or quantum dots forvarious bioapplications.
178 citations
TL;DR: A brief overview of the most recent advances in Ln(3+)-doped luminescent inorganic NPs as sensors is provided, which covers from their chemical and physical fundamentals to biodetection, such as controlled synthesis methodology, surface modification chemistry, optical physics, and their promising applications in diverse bioassays.
Abstract: Trivalent lanthanide (Ln3+)-doped luminescent inorganic nanoparticles (NPs), characterized by long-lived luminescence, large Stokes and/or anti-Stokes shifts, narrow emission bands and high photochemical stability, are considered to be promising candidates as luminescent bioprobes in biomedicine and biotechnology. In this feature article, we provide a brief overview of the most recent advances in Ln3+-doped luminescent inorganic NPs as sensors, which covers from their chemical and physical fundamentals to biodetection, such as controlled synthesis methodology, surface modification chemistry, optical physics, and their promising applications in diverse bioassays, with an emphasis on heterogeneous and homogeneous in vitro biodetection. Finally, some of the most important emerging trends and future efforts toward this active research field are also proposed.
167 citations
TL;DR: In this paper, the authors observe efficient frequency-upconverted stimulated emission from the mid- or near-infrared to the visible region in a novel fluorophore, where the fifth-order dependence on the input light intensity provides much stronger spatial confinement than lower-order nonlinear absorption.
Abstract: Through simultaneous five-photon absorption, scientists observe efficient frequency-upconverted stimulated emission from the mid- or near-infrared to the visible region in a novel fluorophore. The fifth-order dependence on the input light intensity provides much stronger spatial confinement than lower-order nonlinear absorption, thus offering much higher contrast for imaging.
122 citations
TL;DR: After bioconjugation with amino-terminal fragment of urokinase plasminogen activator (uPA), NaScF4:Ln(3+) NPs exhibited specific recognition of cancer cells overexpressed with uPA receptor (uPAR), showing great potentials in tumor-targeted bioimaging.
Abstract: Trivalent lanthanide ions (Ln(3+))-doped inorganic nanoparticles (NPs) as potential luminescent bioprobes have been attracting tremendous interest because of their unique upconversion (UC) and downconversion (DC) luminescence properties. NaScF4, as an important host material, has been rarely reported and its crystal structure remains unclear. Herein, based on the single crystal X-ray diffraction, the space group of NaScF4 crystals was determined to be P31 containing multiple sites of Sc(3+) with crystallographic site symmetry of C1, which was verified by high-resolution photoluminescence spectroscopy of Eu(3+) at low temperature (10 K). Furthermore, monodisperse and size-controllable NaScF4:Ln(3+) NPs were synthesized via a facile thermal decomposition method. The biotinylated NaScF4:Er(3+)/Yb(3+) NPs were demonstrated for their applications as a heterogeneous UC luminescence bioprobe to detect avidin with a detection limit of 180 pM. After bioconjugation with amino-terminal fragment (ATF) of urokinase plasminogen activator (uPA), NaScF4:Ln(3+) NPs also exhibited specific recognition of cancer cells overexpressed with uPA receptor (uPAR, an important marker of tumor biology and metastasis), showing great potentials in tumor-targeted bioimaging.
71 citations
TL;DR: A comprehensive survey of the latest advances made in developing lanthanide-doped inorganic nanoparticles as potential luminescent bioprobes, which covers areas from their fundamental chemical and physical features to bioapplications including controlled synthesis methodology, surface modification chemistry, optical spectroscopy, and their promising applications in diverse fields, with an emphasis on heterogeneous and homogeneous in vitro biodetection of tumor markers and multimodal bioimaging of various tumor tissues as mentioned in this paper.
Abstract: Lanthanide-doped inorganic nanoparticles possess superior physicochemical features such as long-lived luminescence, large antenna-generated Stokes or anti-Stokes shifts, narrow emission bands, high resistance to photobleaching and low toxicity, and thus are regarded as a new generation of luminescent bioprobes as compared to conventional molecular probes like organic dyes and lanthanide chelates. These functional nanoparticles, although most of their bulk counterparts were well studied previously, have attracted renewed interest for their biomedical applications in areas as diverse as biodetection, bioimaging, and disease diagnosis and therapeutics. In this review, we provide a comprehensive survey of the latest advances made in developing lanthanide-doped inorganic nanoparticles as potential luminescent bioprobes, which covers areas from their fundamental chemical and physical features to bioapplications including controlled synthesis methodology, surface modification chemistry, optical spectroscopy, and their promising applications in diverse fields, with an emphasis on heterogeneous and homogeneous in vitro biodetection of tumor markers and multimodal bioimaging of various tumor tissues. Some future prospects and challenges in this rapidly growing field are also summarized.
69 citations
TL;DR: In this article, an efficient broadband excited near-infrared to visible up-conversion was observed in LaF3:Ho3+ as the result of a two-wavelength excitation.
Abstract: An efficient broadband excited near-infrared to visible up-conversion is observed in LaF3:Ho3+ as the result of a two-wavelength excitation. The visible up-conversion emission intensity is greatly enhanced upon simultaneous excitation at 970 nm and 1150 nm, due to an energy transfer up-conversion mechanism. Multi-wavelength excitation based on the ground-state absorption, excited-state absorption, and phonon-coupled absorption of rare-earth ions results in an efficient broadband excited up-conversion emission, which may provide a new approach to fully harvest NIR solar energy and has potential application in solar cells.
63 citations
TL;DR: In this paper, a series of soluble ladder-type tetraphenylene cored chromophores with different terminal groups have been synthesized and their structure-property relationship with regards to various linear optical and nonlinear optical properties has been established.
Abstract: A series of soluble ladder-type tetraphenylene cored chromophores with different terminal groups have been synthesized and their structure–property relationship with regards to various linear optical and nonlinear optical properties has been established. By using the two-photon excited fluorescence method and the nonlinear transmission method, the two-photon absorption (2PA) properties of these chromophores were determined, and they were found to be strongly dependent on the electron-richness of the ladder-type tetraphenylene core, as well as the terminal groups. The introduction of strong electron donors (N-alkyl) in both the central core and the terminals led to a chromophore with a high 2PA cross-section value of 2137 GM. Optical limiting behaviors of the synthesized chromophores in THF were investigated by using a femto-second ultra-fast laser. 2PA coefficients for these chromophores in THF (5 mM) ranged from 0.131–0.256 cm GW−1. The ladder-type tetraphenylene cored chromophore with the highest 2PA cross-section value exhibited the best optical limiting performance, as evidenced by light transmission as low as 19.1% at 770 nm under an intensity of 99.6 GW cm−2. The excellent optical limiting performance of these chromophores makes them useful in photonic or optoelectronic devices for protecting human eyes and optical sensors, as well as for stabilizing light sources in optical communications.
62 citations
TL;DR: Er3+-doped In2O3 NPs, synthesized via a facile sol–gel solvothermal method, exhibit intense and well-resolved NIR-to-NIR downshifting (DS) and NIR to visible upconversion (UC) dual-mode luminescence upon NIR excitation at 808 and 980 nm, respectively.
Abstract: Luminescent lanthanide-doped nanoparticles (NPs) excitable in the near-infrared (NIR) spectral region are highly desired as new optical bioprobes in the fields of biological assays and medical imaging. Er3+-doped In2O3 NPs, synthesized via a facile sol–gel solvothermal method, exhibit intense and well-resolved NIR-to-NIR downshifting (DS) and NIR-to-visible upconversion (UC) dual-mode luminescence upon NIR excitation at 808 and 980 nm, respectively. Forty-one crystal-field levels below 23 000 cm–1 were identified for Er3+ at a single lattice site of C2 symmetry in In2O3 NPs by means of high-resolution site-selective NIR spectroscopy at 10 K and room temperature. Furthermore, the luminescence dynamics for the UC emissions were systematically investigated, and various UC processes were clearly distinguished based on excited state dynamics and rate equation analysis. Mediated by the long-lived intermediate states of 4I11/2 and 4I13/2, the decay times of 4F9/2 (or 4S3/2) due to energy transfer upconversion (E...
46 citations
TL;DR: This concept article introduces the controlled synthesis of lanthanide-doped inorganic multimodal bioprobes, including core-shell structured and single-phase nanoparticles, and demonstrates different design strategies for achieving dual-modal functionalization of nanoprobes.
Abstract: Multimodal bioACHTUNGREprobes, which integrate the ad-vantages of different diagnostic modes into one singleparticle, can overcome the current limitations of sensi-tivity and resolution in medical assays and significantlyimprove the outcome of existing therapeutics. Lantha-nide-doped inorganic multimodal bioACHTUNGREprobes, which areemerging as a promising new class of optical/magneticmultimodal bioACHTUNGREprobes, have been long sought-after andhave recently attracted revived interest owing to theirdistinct optical and magnetic properties. In this conceptarticle, we introduce the controlled synthesis of lantha-nide-doped inorganic multimodal bioACHTUNGREprobes, includingcore–shell structured and single-phase nanoparticles,and demonstrate different design strategies for achiev-ing dual-modal functionalization of nanoprobes. In par-ticular, we highlight the most recent advances in bio-ACHTUNGREdetection, bioimaging, targeted drug delivery, and thera-py based on these nanoparticles.Keywords: lanthanides · magnetic properties · multi-ACHTUNGREmodal bio ACHTUNGREprobes · nanocrystals · photoluminescence
TL;DR: A facile one-step solvothermal approach to fabricate targetable and biocompatible β-NaYF4:Yb,Gd,Tm upconversion nanoparticles (UCNPs) with bimodal-signals using hyaluronic acid (HA) as a multifunctional molecule is reported.
Abstract: Bionanoparticles and nanostructures with high biocompatibility and stability, low toxicity, diversification of imaging modality, and specificity of targeting to desired organs or cells are of great interest in nanobiology and medicine. However, integrating all of these desired features into a single bionanoparticle, which can be applied to biomedical applications and eventually in clinical prediagnosis and therapy, is still a challenge. We herein report a facile one-step solvothermal approach to fabricate targetable and biocompatible β-NaYF4:Yb,Gd,Tm upconversion nanoparticles (UCNPs) with bimodal-signals (near-infrared (NIR) fluorescence and magnetic resonance (MR) signals) using hyaluronic acid (HA) as a multifunctional molecule. The prepared UCNPs with low toxicity are successfully applied for in vitro and in vivo targeted tumor imaging. The developed biomimetic surface modification approach for the synthesis of biomolecule-guided multifunctional UCNPs holds great potential applications in medical diag...