Lanthanide-based luminescent hybrid materials.

Uniform, spherical-shaped TiO2:Eu nanoparticles with different doping concentrations have been synthesized through controlled hydrolysis of titanium tetrabutoxide under appropriate pH and temperature in the presence of EuCl3·6H2O. Through air annealing at 500°C for 2 h, the amorphous, as-grown nanoparticles could be converted to a pure anatase phase. The morphology, structural, and optical properties of the annealed nanostructures were studied using X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy [EDS], and UV-Visible diffuse reflectance spectroscopy techniques. Optoelectronic behaviors of the nanostructures were studied using micro-Raman and photoluminescence [PL] spectroscopies at room temperature. EDS results confirmed a systematic increase of Eu content in the as-prepared samples with the increase of nominal europium content in the reaction solution. With the increasing dopant concentration, crystallinity and crystallite size of the titania particles decreased gradually. Incorporation of europium in the titania particles induced a structural deformation and a blueshift of their absorption edge. While the room-temperature PL emission of the as-grown samples is dominated by the 5D0 - 7Fj transition of Eu+3 ions, the emission intensity reduced drastically after thermal annealing due to outwards segregation of dopant ions.

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Effects of crystallization and dopant concentration on the emission behavior of TiO2:Eu nanophosphors

Sasidharan Swarnalatha Lucky,†,§ Khee Chee Soo,‡ and Yong Zhang*,†,§,∥ †NUS Graduate School for Integrative Sciences & Engineering (NGS), National University of Singapore, Singapore, Singapore 117456 ‡Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore 169610 Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore, Singapore 117576 College of Chemistry and Life Sciences, Zhejiang Normal University, Zhejiang, P. R. China 321004

Nanoparticles in photodynamic therapy.

Yuming Yang,†,§ Qiang Zhao,‡,§ Wei Feng,† and Fuyou Li*,† †Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P. R. China ‡Key Laboratory for Organic Electronics and Information Displays (KLOEID) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing 210046, P. R. China.

Luminescent chemodosimeters for bioimaging.

Applications in Theranostics Guanying Chen,*,†,‡ Hailong Qiu,†,‡ Paras N. Prasad,*,‡,§ and Xiaoyuan Chen* †School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China ‡Department of Chemistry and the Institute for Lasers, Photonics, and Biophotonics, University at Buffalo, State University of New York, Buffalo, New York 14260, United States Department of Chemistry, Korea University, Seoul 136-701, Korea Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892-2281, United States

Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

The determination of the dominant factor for the enantioselectivity and reactivity of lipase-catalyzed reactions of binaphthyl compounds is of wide concern. To understand the stereo-dependent behavior of 2,2-binaphthyl compounds towards lipase, we established a platform for effectively evaluating the reactivity and enantioselectivity of lipase towards binaphthyl compounds by investigating the binding interactions between substrate and lipase. Penicillium expansum lipase (PEL) and three 2-amino-2′-hydroxy-1,1′-binaphthyl compounds (NBs) with different linker lengths were selected as the model lipase and substrates, respectively, in this study. The key interaction parameters such as binding affinities, binding modes, and thermodynamic parameters between NBs and PEL were determined for the first time, and the results revealed that the substrate–lipase binding interaction is a prerequisite for successful lipase-catalyzed reaction. The effect of binding discrepancies of NBs with different alkyl chain lengths on lipase reactivity and enantioselectivity was also unveiled. From the analytical results of NB–PEL binding interactions, a PEL-catalyzed two-step resolution strategy was further established and optimized for the gram-scale synthesis of optically pure NB. The investigation on the molecular interaction between NBs and PEL showed great promise for rationally guiding the synthesis of binaphthyl derivatives that are suitable for efficient optical resolution by the commercially available lipase.

Deciphering molecular interaction of binaphthyl compounds with Penicillium expansum lipase: enantioselectivity and reactivity prediction for lipase

Conventional single-modal bioprobing is usually not perfect and insufficient to obtain all the necessary information in clinical diagnosis Multimodal bioprobes, which integrate the advantages of different diagnostic modes into one single particle, can overcome the current limitations of sensitivity and resolution in medical assays and significantly improve the outcome of existing therapeutics Lanthanide-doped inorganic multimodal bioprobes, emerging as a promising new class of optical/magnetic multimodal bioprobes, have been long sought and recently attracted reviving interest owing to their distinct optical and magnetic properties In this chapter, we introduce the controlled synthesis of lanthanide-doped inorganic multimodal bioprobes including core–shell-structured and single-phase nanoparticles and demonstrate different design strategies for achieving dual-modal functionalization of nanoprobes In particular, we highlight the most recent advances in biodetection, bioimaging, and targeted drug delivery and therapy based on these lanthanide-doped multimodal nanoparticles

Multimodal Biosensing Based on Lanthanide-Doped Nano-bioprobes

State Key Laboratory of Structural Chemistry, National Engineering Research Center for OptoelectronicCrystalline Materials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences,Fuzhou, Fujian 350002, China, Chemistry DiVision, Argonne National Laboratory, Argonne, Illinois 60439,U.S.A., and Department of Physics, UniVersity of Science and Technology of China, Hefei, Anhui 230026,ChinaReceiVed: September 22, 2006; In Final Form: February 25, 2007

Excited-State Dynamics of Er 3+ in Gd2O3 Nanocrystals

In article 1600197, Xueyuan Chen and co‐workers report a novel luminescent bioassay technique, namely, dissolution‐enhanced luminescence bioassay based on inorganic lanthanide nanoprobes, for ultrasensitive in‐vitro detection of tumor markers in human sera or saliva, such as carcinoembryonic antigen, prostate specific antigen and alpha‐fetoprotein, with detection sensitivities several orders of magnitude improvement relative to current commercial bioassays.

Tumor Marker Detection: Ultrasensitive Luminescent In Vitro Detection for Tumor Markers Based on Inorganic Lanthanide Nano-Bioprobes (Adv. Sci. 11/2016)

https://aip.scitation.org/doi/pdf/10.1063/5.0127364

Xueyuan Chen

Papers

Deciphering molecular interaction of binaphthyl compounds with Penicillium expansum lipase: enantioselectivity and reactivity prediction for lipase

Multimodal Biosensing Based on Lanthanide-Doped Nano-bioprobes

Excited-State Dynamics of Er 3+ in Gd2O3 Nanocrystals

Tumor Marker Detection: Ultrasensitive Luminescent In Vitro Detection for Tumor Markers Based on Inorganic Lanthanide Nano-Bioprobes (Adv. Sci. 11/2016)

Pursuing phosphor materials for laser-driven lighting