Y
Y Inui
Publications - 7
Citations - 3719
Y Inui is an academic researcher. The author has contributed to research in topics: Microsome & Cytochrome P450. The author has an hindex of 7, co-authored 7 publications receiving 3654 citations.
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Journal Article
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
TL;DR: The results presented in this study provide useful information for the study of drug biotransformation in humans and for the basis of drug toxicities, carcinogenesis and teratogenesis.
Journal ArticleDOI
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes
TL;DR: It is indicated that several P450 enzymes, particularly P450 2E1 and 2A6, catalyze metabolic activation of nitrosamine derivatives including N-nitrosodialkylamines and tobacco-smoke-related nitrosamines in human liver microsomes.
Journal Article
Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.
Tsutomu Shimada,Hiroshi Yamazaki,M Mimura,N. Wakamiya,Yune-Fang Ueng,F. P. Guengerich,Y Inui +6 more
TL;DR: Results suggest that in human fetal livers at least two P450 enzymes, a form of P450 that is immunoreactive P4501A1 and P4503A7, are actually expressed and these enzymes are suggested as being involved in the activation of the (+)- and (-)-enantiomers of 7,8-dihydroxy-7, 8- dihydrobenzo[a]pyrene and the carcinogenic mycotoxins.
Journal Article
Characterization of cytochrome P-450 2B6 in human liver microsomes.
M Mimura,T. Baba,Hiroshi Yamazaki,Shigeru Ohmori,Y Inui,Frank J. Gonzalez,F. P. Guengerich,Tsutomu Shimada +7 more
TL;DR: A cytochrome P-450 (P-450) enzyme of the CYP2B subfamily was partially purified from human liver microsomes and characterized with respect to immunochemical properties, N-terminal amino acid sequence, and catalytic activities toward typical P- 450 substrates.
Journal ArticleDOI
Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009).
Hiroshi Yamazaki,Yoshimitsu Oda,Yoshihiko Funae,Susumu Imaoka,Y Inui,F. P. Guengerich,Tsutomu Shimada +6 more
TL;DR: Results indicate that NDMA and NDEA are oxidized to gentoxoic products by rat liver microsomes and that a P450 2E1 enzyme plays a major role in the activation of these two potent carcinogens.