F
Frank J. Gonzalez
Researcher at National Institutes of Health
Publications - 70
Citations - 22321
Frank J. Gonzalez is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Farnesoid X receptor. The author has an hindex of 25, co-authored 66 publications receiving 20910 citations. Previous affiliations of Frank J. Gonzalez include University of Arizona & University of Illinois at Chicago.
Papers
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Journal ArticleDOI
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature.
David R. Nelson,Tetsuya Kamataki,David J. Waxman,F P Guengerich,Ronald W. Estabrook,René Feyereisen,Frank J. Gonzalez,Minor J. Coon,Irwin C. Gunsalus,Osamu Gotoh +9 more
TL;DR: The likelihood that this ancient gene superfamily has existed for more than 3.5 billion years, and that the rate of P450 gene evolution appears to be quite nonlinear, is discussed.
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Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators.
Susanna S.T. Lee,Thierry Pineau,John Drago,Eric J. Lee,Jennie W. Owens,Deanna L. Kroetz,Pedro M. Fernández-Salguero,Heiner Westphal,Frank J. Gonzalez +8 more
TL;DR: It is demonstrated that mPPAR alpha is the major isoform required for mediating the pleiotropic response resulting from the actions of peroxisome proliferators.
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Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
Christopher J. Sinal,Masahiro Tohkin,Masaaki Miyata,Jerrold M. Ward,Gilles Lambert,Frank J. Gonzalez +5 more
TL;DR: It is demonstrated that FXR/BAR is critical for bile acid and lipid homeostasis by virtue of its role as an intracellular bile Acid sensor.
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P450 genes: structure, evolution, and regulation
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Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Sander Kersten,Josiane Seydoux,Jeffrey M. Peters,Frank J. Gonzalez,Béatrice Desvergne,Walter Wahli +5 more
TL;DR: It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPAR α mRNA is induced during fasting in wildtype mice, indicating that PPARα plays a pivotal role in the management of energy stores during fasting.