Yael Kalma

TL;DR: A method for obtaining parallel, highly accurate gene expression measurements from thousands of designed promoters is devised and applied to measure the effect of systematic changes in the location, number, orientation, affinity and organization of transcription-factor binding sites and nucleosome-disfavoring sequences.

TL;DR: The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes and up-regulates the expression of genes not previously described as E1F target genes, which suggest that E 2F affects cell cycle progression both at S phase and during mitosis.

TL;DR: It is demonstrated here that LAP2beta is also capable of reducing the transcriptional activity of the E2F-DP complex and that it is more potent than mGCL in doing so.

TL;DR: A novel experimental assay termed BunDLE-seq that provides quantitative measurements of TF binding to thousands of fully designed sequences of 200 bp in length within a single experiment and shows that TF-specific models based on the sequence or DNA shape of the regions flanking the core binding site are highly predictive of the measured differential TF binding.

TL;DR: The biopsy-induced increase in the expression of UPIb and other genes encoding membrane proteins supports the possible importance of the membrane structure and stability during implantation.