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Yafei Huang
Researcher at Washington University in St. Louis
Publications - 4
Citations - 791
Yafei Huang is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Amyloidosis & Amyloid. The author has an hindex of 4, co-authored 4 publications receiving 673 citations.
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Journal ArticleDOI
Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology
Jee Hoon Roh,Yafei Huang,Adam W. Bero,Tom Kasten,Floy R. Stewart,Randall J. Bateman,David M. Holtzman +6 more
TL;DR: It is suggested that changes in the sleep-wake cycle may be caused by Aβ accumulation, andSleep-wake behavior and diurnal fluctuation of Aβ in the central nervous system may be functional and biochemical indicators, respectively, of A β-associated pathology.
Journal ArticleDOI
Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System
Yafei Huang,Rachel Potter,Wendy Sigurdson,Anna Santacruz,Shirley Shih,Yo-El Ju,Tom Kasten,John C. Morris,Mark A. Mintun,Stephen P. Duntley,Randall J. Bateman +10 more
TL;DR: A reduction in the linear increase in the Aβ levels in CSF samples that is associated with amyloid deposition and a decreased CSF Aβ diurnal pattern associated with increasing age disrupt the normal physiology of Aβ dynamics and may contribute to AD.
Journal ArticleDOI
β-Amyloid Dynamics in Human Plasma
Yafei Huang,Rachel Potter,Wendy Sigurdson,Tom Kasten,Rose Connors,John C. Morris,Tammie L.S. Benzinger,Mark A. Mintun,Mark A. Mintun,Tim Ashwood,Mats Ferm,Samantha L. Budd,Randall J. Bateman +12 more
TL;DR: Plasma Aβ demonstrates a circadian pattern that is reduced in amplitude with increasing age but is unaffected by amyloid deposition, and there is no evidence that plasma and CSF Aβ concentrations were related on an hourly or individual basis.
Journal ArticleDOI
Diurnal Patterns of Soluble Amyloid Precursor Protein Metabolites in the Human Central Nervous System
Justyna Dobrowolska,Tom Kasten,Yafei Huang,Tammie L.S. Benzinger,Wendy Sigurdson,Vitaliy Ovod,John C. Morris,Randall J. Bateman +7 more
TL;DR: Diurnal patterns in sAPPα, sAPPβ, Aβ40, and Aβ42, which diminish with increased age, support the hypothesis that APP is diurnally regulated in the human central nervous system and thus results in Aβ diurnal patterns and the four APP metabolites were positively correlated in all participants without cerebral Aβ deposits.