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Yajie Gong
Researcher at Huazhong University of Science and Technology
Publications - 50
Citations - 1052
Yajie Gong is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 16, co-authored 49 publications receiving 800 citations. Previous affiliations of Yajie Gong include University of the Sciences.
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Journal ArticleDOI
Exome-wide analyses identify low-frequency variant in CYP26B1 and additional coding variants associated with esophageal squamous cell carcinoma
Jiang Chang,Rong Zhong,Jianbo Tian,Jiaoyuan Li,Kan Zhai,Kan Zhai,Juntao Ke,Jiao Lou,Wei Chen,Beibei Zhu,Na Shen,Yi Zhang,Ying Zhu,Yajie Gong,Yang Yang,Danyi Zou,Xiating Peng,Zhi Zhang,Xuemei Zhang,Kun Huang,Tangchun Wu,Chen Wu,Xiaoping Miao,Dongxin Lin +23 more
TL;DR: Exome-wide analyses identify low-frequency coding variants associated with esophageal squamous cell carcinoma and one of the risk variants is associated with enhanced enzymatic activity and lower levels of all-trans retinoic acid in serum.
Journal ArticleDOI
A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding.
Jing Gong,Jianbo Tian,Jiao Lou,Juntao Ke,Lu Li,Jiaoyuan Li,Yang Yang,Yajie Gong,Ying Zhu,Yi Zhang,Rong Zhong,Jiang Chang,Xiaoping Miao +12 more
TL;DR: Findings indicated that rs2147578 in lnc-LAMC2-1:1 might be a genetic modifier for the development of CRC.
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A functional polymorphism located at transcription factor binding sites, rs6695837 near LAMC1 gene, confers risk of colorectal cancer in Chinese populations.
Jiao Lou,Jing Gong,Juntao Ke,Jianbo Tian,Yi Zhang,Jiaoyuan Li,Yang Yang,Ying Zhu,Yajie Gong,Lu Li,Jiang Chang,Rong Zhong,Xiaoping Miao +12 more
TL;DR: Findings strongly suggest that the functional SNP located at TFBSs, rs6695837 might contribute to CRC susceptibility, and the exact biological mechanism awaits further research.
Journal ArticleDOI
A Rare Missense Variant in TCF7L2 Associates with Colorectal Cancer Risk by Interacting with a GWAS-Identified Regulatory Variant in the MYC Enhancer
Jiang Chang,Jianbo Tian,Yang Yang,Rong Zhong,Jiaoyuan Li,Kan Zhai,Juntao Ke,Jiao Lou,Wei Chen,Beibei Zhu,Na Shen,Yi Zhang,Yajie Gong,Ying Zhu,Danyi Zou,Xiating Peng,Kun Huang,Xiaoping Miao +17 more
TL;DR: Exome-wide association analysis identifies a rare missense variant in TCF7L2 and a common regulatory variant in ATF1 as susceptibility factors of colorectal cancer.
Journal ArticleDOI
CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer.
Jianbo Tian,Zhihua Wang,Shufang Mei,Nan Yang,Yang Yang,Juntao Ke,Ying Zhu,Yajie Gong,Danyi Zou,Xiating Peng,Xiaoyang Wang,Hao Wan,Rong Zhong,Jiang Chang,Jing Gong,Jing Gong,Leng Han,Xiaoping Miao +17 more
TL;DR: A computational pipeline to identify splicing quantitative trait loci (sQTLs), genetic variants that affect AS events, and a user-friendly database, CancerSplicingQTL, which provides an informative sQTL resource for further characterizing the potential functional roles of SNPs that control transcript isoforms in human cancer.