Yan-Hua Bing

TL;DR: The results indicated that natural stimulus of whisker pad neither evoked complex spikes, nor fired simple spikes, but induced inhibition in PCs, suggesting that the interneuron network are rapid activated and involved in controlling the spread of sensory information processing in mouse cerebellar cortex folium Crus II.

TL;DR: Findings indicated that tactile stimulation induced asynchronous parallel fiber excitatory inputs onto the dendrites of PCs, and failed to evoke strong EPSCs and spike firing in PCs, but induced the rapid activation of strong GABAA receptor-mediated inhibitory postsynaptic currents in the somata and dendrite of PCs in the cerebellar cortex Crus II in urethane-anesthetized mice.

TL;DR: The results suggest that the MLIs network acts as a low-pass filter during the processing of high-frequency sensory information in cerebellar granule cells, which is cut-off by molecular layer interneurons (MLIs).

TL;DR: Application of propofol facilitates presynaptic GABAB receptors, resulting in a depression of PF-PC synaptic transmission via PKA signaling pathway in mouse cerebellar cortex, and the results suggest that the interaction with GABAB receptor may contribute to the general anesthetic action of prop ofol.

TL;DR: The results indicate that ethanol inhibits the facial stimulation-evoked outward currents by activating presynaptic CB1 receptors via the PKA signaling pathway, and suggest that ethanol overdose impairs sensory information processing, at least in part, by inhibiting GABA release from molecular layer interneurons onto PCs.