Yan-yan Guo

TL;DR: It is demonstrated that an HT time window in mice can be prolonged by cotreatment with a CB1 agonist, implying a potential strategy for HT in long-term menopausal women.

TL;DR: The hypothesis that impaired ER–caveolae coupling contributes to the mental retardation of FXS is tested.

TL;DR: In cultured cortical neurons, treatment with ZBD‐2 attenuated excitotoxicity induced by N‐methyl‐d‐aspartate (NMDA) exposure and systemic treatment provided significant neuroprotection in mice subjected to middle cerebral artery occlusion, providing direct evidence that neuroprotection by Z BD‐2 is partially mediated by inhibiting GluN2B‐containing NMDA receptor‐mediated excitOToxicity.

TL;DR: Findings highlight an epigenetic mechanism underlying LXR β deficits linked to CIP, and LXRβ activation may represent a potential novel target for the treatment of CIP with an alteration in inflammation responses and synaptic transmission in ACC.

TL;DR: In this article, the authors used the conditioned place preference (CPP) paradigm to investigate nicotine use disorder behavior in mice and found that G protein-coupled receptor 55 (GPR55) activation significantly reduced nicotine-CPP behavior by decreasing spontaneous excitatory postsynaptic currents frequency in the nucleus accumbens (NAc) and the release of dopamine in serum.