Min Zhuo

TL;DR: It is shown that overexpression ofNMDA receptor 2B (NR2B) in the forebrains of transgenic mice leads to enhanced activation of NMDA receptors, facilitating synaptic potentiation in response to stimulation at 10–100 Hz, suggesting that genetic enhancement of mental and cognitive attributes such as intelligence and memory in mammals is feasible.

TL;DR: Results are consistent with the hypothesis that NO and CO, either alone or in combination, serve as retrograde messages that produce activity-dependent presynaptic enhancement during LTP.

TL;DR: Both dopamine D1/D5 receptor agonists, which are positively coupled to adenylyl cyclase, and a cAMP phosphodiesterase inhibitor ameliorated the physiological as well as the memory defects, consistent with the idea that the cAMP-protein kinase A-dependent signaling pathway is defective in age-related spatial memory loss.

TL;DR: It is reported that the activation of the NR2B and NR2A subunits of the NMDA receptor is critical for the induction of cingulate LTP, regardless of the induction protocol.

TL;DR: It is reported here that an inhibitor of guanylyl cyclase blocks the induction of LTP in the CA1 region of hippocampal slices, and activity-dependent long-lasting enhancement of the excitatory postsyn-aptic potential is produced.