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Yana K. Reshetnyak
Researcher at University of Rhode Island
Publications - 130
Citations - 5657
Yana K. Reshetnyak is an academic researcher from University of Rhode Island. The author has contributed to research in topics: Lipid bilayer & Membrane. The author has an hindex of 40, co-authored 119 publications receiving 4859 citations. Previous affiliations of Yana K. Reshetnyak include Russian Academy of Sciences & Autonomous University of Barcelona.
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Journal ArticleDOI
Membrane protein folding: beyond the two stage model.
Donald M. Engelman,Yang Chen,Chen-Ni Chin,A. Rachael Curran,Ann M. Dixon,Allison D. Dupuy,Albert S. Lee,Ursula Lehnert,Erin E. Matthews,Yana K. Reshetnyak,Alessandro Senes,Jean-Luc Popot +11 more
TL;DR: A three stage model is presented which gives considerations to ligand binding, folding of extramembranous loops, insertion of peripheral domains and the formation of quaternary structure.
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Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo
Oleg A. Andreev,Allison D. Dupuy,Michael Segala,Srikanth Sandugu,David A. Serra,Clinton O. Chichester,Donald M. Engelman,Yana K. Reshetnyak +7 more
TL;DR: The pHLIP [pH (low) insertion peptide] was used to target acidic tissue in vivo, including acidic foci in tumors, kidneys, and inflammatory sites as discussed by the authors.
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Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix
TL;DR: A related peptide is used, pH (low) insertion peptide, to translocate cargo molecules attached to its C terminus across the plasma membranes of living cells, because a high extracellular acidity is characteristic of a variety of pathological conditions.
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A Monomeric Membrane Peptide that Lives in Three Worlds: In Solution, Attached to, and Inserted across Lipid Bilayers
Yana K. Reshetnyak,Yana K. Reshetnyak,Michael Segala,Oleg A. Andreev,Oleg A. Andreev,Donald M. Engelman +5 more
TL;DR: A key aspect of the mechanism is examined, showing that pHLIP is monomeric in each of its three major states: soluble in water near neutral pH, bound to the surface of a membrane nearneutral pH, and inserted across the membrane as an alpha-helix at low pH (state III).
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Family of pH (low) insertion peptides for tumor targeting
Dhammika Weerakkody,Anna Moshnikova,Mak S. Thakur,Valentina Moshnikova,Jennifer Daniels,Donald M. Engelman,Oleg A. Andreev,Yana K. Reshetnyak +7 more
TL;DR: A library of 16 rationally designed pHLIP variants is reported on, showing how the tuning of the biophysical properties of peptide–lipid bilayer interactions alters tumor targeting, distribution in organs, and blood clearance.