Anna Moshnikova

TL;DR: A library of 16 rationally designed pHLIP variants is reported on, showing how the tuning of the biophysical properties of peptide–lipid bilayer interactions alters tumor targeting, distribution in organs, and blood clearance.

TL;DR: A probe that uses a pH low insertion peptide to locate a pH-sensing dye at acidic cell surfaces is developed and it is found that the probe can measure surface pH, which is correlated with tumor aggressiveness and is sensitive to cell glycolytic activity.

TL;DR: In this article, a method for the preferential targeting of gold nanoparticles to a tumor in a mouse model is described, which is based on the use of the pH Low Insertion Peptide (pHLIP), which targets various imaging agents to acidic tumors.

TL;DR: The pHLIP technology can substantially improve the delivery of gold nanoparticles to tumors by providing specificity of targeting, enhancing local concentration in tumors, and distributing nanoparticles throughout the entire tumor mass where they remain for an extended period (several days), which is beneficial for radiation oncology and imaging.

TL;DR: The crystal structure of Ras in complex with the Ras binding domain (RBD) of NORE1A/RAPL is described and it is demonstrated that the enlarged interface provides a rationale for an exceptionally long lifetime of the complex.