Y
Yang-Ja Lee
Researcher at National Institutes of Health
Publications - 4
Citations - 1958
Yang-Ja Lee is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Mitochondrion & Mitochondrial apoptosis-induced channel. The author has an hindex of 3, co-authored 3 publications receiving 1844 citations.
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Journal ArticleDOI
Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis
TL;DR: It is demonstrated in this study that mitochondrial fragmentation per se does not result in apoptosis, but it is provided further evidence that multiple components of the mitochondrial morphogenesis machinery can positively and negatively regulate apoptosis.
Journal ArticleDOI
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
Mariusz Karbowski,Yang-Ja Lee,Brigitte Gaume,Seon-Yong Jeong,Stephan Frank,Amotz Nechushtan,Ansgar Santel,Margaret T. Fuller,Carolyn L. Smith,Richard J. Youle +9 more
TL;DR: It is suggested that Bax participates in apoptotic fragmentation of mitochondria, a proapoptotic member of the Bcl-2 family that translocates to discrete foci on mitochondria during the initial stages of apoptosis, which subsequently become mitochondrial scission sites.
Journal ArticleDOI
Bcl‐xL sequesters its C‐terminal membrane anchor in soluble, cytosolic homodimers
Seon-Yong Jeong,Brigitte Gaume,Yang-Ja Lee,Yi-Te Hsu,Seung-Wook Ryu,Soo-Han Yoon,Richard J. Youle +6 more
TL;DR: Both mitochondrial import and antiapoptotic activity of different Bcl‐xL mutants correlate with their ability to form homodimers, and analysis of mutants demonstrates that the C‐terminal lysine residue and the BH3‐binding pocket are required for homodimerization.
Posted ContentDOI
Integrative transcriptomic and metabolic analyses of the mammalian hibernating brain identifies a key role for succinate dehydrogenase in ischemic tolerance
Joshua D. Bernstock,Cory M. Willis,M Garcia-Segura,Edoardo Gaude,Daniela Anni,Yang-Ja Lee,Luke Thomas,Alva M. Casey,Nunzio Vicario,Tommaso Leonardi,Alexandra M. Nicaise,Florian Gessler,Saef Izzy,Mario Rosario Buffelli,Jakob Seidlitz,Shriya Srinivasan,Michael P. Murphy,Margaret Ashcroft,Marco Cambiaghi,John M. Hallenbeck,Luca Peruzzotti-Jametti +20 more
TL;DR: This article showed that hibernation in thirteen-lined ground squirrels (TLGS) leads to major changes in the expression of genes involved in oxidative phosphorylation and this is correlated with an accumulation of the tricarboxylic acid (TCA) cycle intermediates citrate, cis-aconitate, and α-ketoglutarate-αKG.