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Richard J. Youle

Researcher at National Institutes of Health

Publications -  255
Citations -  74587

Richard J. Youle is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Mitochondrion & Mitophagy. The author has an hindex of 104, co-authored 246 publications receiving 65584 citations. Previous affiliations of Richard J. Youle include University of Maryland, College Park & Laboratory of Molecular Biology.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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The BCL-2 protein family: opposing activities that mediate cell death

Richard J. Youle, +1 more
- 01 Jan 2008 - 
TL;DR: New insights into interactions among BCL-2 family proteins reveal how these proteins are regulated, but a unifying hypothesis for the mechanisms they use to activate caspases remains elusive.
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Derek P. Narendra, +3 more
- 01 Dec 2008 - 
TL;DR: It is shown that Parkin is selectively recruited to dysfunctional mitochondria with low membrane potential in mammalian cells and this recruitment promotes autophagy of damaged mitochondria and implicate a failure to eliminate dysfunctional mitochondira in the pathogenesis of Parkinson's disease.
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Mechanisms of mitophagy

Richard J. Youle, +2 more
- 01 Jan 2011 - 
TL;DR: Mitophagy, the specific autophagic elimination of mitochondria, has been identified in yeast, and in mammals during red blood cell differentiation, mediated by NIP3-like protein X (NIX; also known as BNIP3L).
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Mitochondrial Fission, Fusion, and Stress

Richard J. Youle, +1 more
- 31 Aug 2012 - 
TL;DR: In their Perspective, Hoppins and Nunnari explain that the endoplasmic reticulum is an active participant in mitochondrial division and discuss how mitochondrial dynamics and cell death are linked.