S
Saef Izzy
Researcher at Brigham and Women's Hospital
Publications - 72
Citations - 2229
Saef Izzy is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Medicine & Traumatic brain injury. The author has an hindex of 13, co-authored 51 publications receiving 1224 citations. Previous affiliations of Saef Izzy include University of Massachusetts Medical School & Lahey Hospital & Medical Center.
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Journal ArticleDOI
Microglia in neurodegeneration.
TL;DR: The immune checkpoints that control microglial functions are considered and how their imbalance and subsequent neuroinflammation leads to neurodegeneration is discussed.
Journal ArticleDOI
Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift.
TL;DR: A new paradigm to study innate immune cells following TBI is proposed that moves away from the existing M1/M2 classification of activation states toward a stimulus- and disease-specific understanding of polarization state based on transcriptomic and proteomic profiling.
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Neurological toxicities associated with chimeric antigen receptor T-cell therapy.
Daniel B. Rubin,Daniel B. Rubin,Husain H Danish,Husain H Danish,Ali Basil Ali,Karen Li,Sarah LaRose,Andrew D. Monk,David J. Cote,Lauren Spendley,Angela H Kim,Matthew Robertson,Matthew Torre,Timothy R. Smith,Saef Izzy,Caron A. Jacobson,Jong Woo Lee,Henrikas Vaitkevicius +17 more
TL;DR: Focal neurological deficits are frequently observed after chimeric antigen receptor T-cell therapy and are associated with regional EEG abnormalities, FDG-PET hypometabolism, and elevated velocities on transcranial Doppler ultrasound.
Journal ArticleDOI
Self-Fulfilling Prophecies Through Withdrawal of Care: Do They Exist in Traumatic Brain Injury, Too?
TL;DR: Factors associated with withdrawal of care in moderate-severe traumatic brain injury patients, and how WOC may affect short-term mortality and receipt of neurosurgery were examined, finding WOC was the most important predictor of in-hospital mortality.
Journal ArticleDOI
Diffusion tensor imaging in acute-to-subacute traumatic brain injury: a longitudinal analysis
Brian L. Edlow,William A. Copen,Saef Izzy,Khamid Bakhadirov,Andre van der Kouwe,Mel B. Glenn,Steven M. Greenberg,David M. Greer,David M. Greer,Ona Wu +9 more
TL;DR: Variability in acute FA correlations with outcome suggests that the optimal timing of DTI for TBI prognostication may be in the subacute period, and white matter FA declined during the acute-to-subacute stages of TBI.