Objective
To study the protective effect of the Mixture of Shengmai Powder and Danshen Decoction (生脉散丹参饮合剂, abbreviated as the Mixture) in the rat model with type 2 diabetic cardiomyopathy in the rat model with type 2 diabetic cardiomyopathy, abbreviated as the Mixture) in the rat model with type 2 diabetic cardiomyopathy (DCM).

study on the protective effect of the Mixture of Shengmai Powder and Danshen Decoction (生脉散丹参饮合剂) on the myocardium of diabetic cardiomyopathy in the rat model

Objective:To study the effect of Yiqi Yangyin Huoxue(YQYYHX)recipe against diabetic extremital gangrene (DEG) in ratsMethods:In order to establish rat model with DEG,male Wistar rats were injected with moderate dose of steptozotocin (STZ),and then the room temperature was down regulated appropriatelyDiabetes mellitus (DM) rats were randomly divided into two groups:DM treated group and DM control group,then the DM treated group was treated with YQYYHX recipeAt the same time,each group's fasting plasma glucose (FPG),triglyceride (TG),total cholesterol (TCh) and fasting insulin (FINS) level were measured before and after the animal models were establishedAfter experiment,SOD,NOS,NO and MDA in pancreatic islet were measured,and the index of β-cell's function in HOMA (HBCI) was also calculated,in addition,each group's body weight (BW),water drinking amount (WDA) and syndrome of DEG were measuredResults:At the beginning of the experiment,compared with normal group,FPG,TG,TCh and WDA in DM group increased significantly (P005),while BW,FINS level and HBCI remarkably decreased (P005)At the end of the experiment,compared with the control group,FPG,TG,TCh,NO,NOS,MDA and WDA in the DM treated group significantly lowered (P005),while BW,FINS level,SOD and HBCI remarkably increased (P005),syndrome of DEG significantly mitigated too (P005)Conclusion:YQYYHX recipe can improve the β-cell's function of diabetic rats,increase FINS and HBCI,decrease FPG,TG,TCh,and be effective in treating diabetic rats with DEG

Yang Wu-bia

Papers

Effect of Yiqi Yangyin Huoxue recipe against diabetic extremital gangrene in rats