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Yang Xu
Researcher at Fudan University
Publications - 71
Citations - 4891
Yang Xu is an academic researcher from Fudan University. The author has contributed to research in topics: Hepatocellular carcinoma & Cancer. The author has an hindex of 26, co-authored 68 publications receiving 4171 citations. Previous affiliations of Yang Xu include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
Intratumoral Balance of Regulatory and Cytotoxic T Cells Is Associated With Prognosis of Hepatocellular Carcinoma After Resection
Qiang Gao,Shuang-Jian Qiu,Jia Fan,Jian Zhou,Xiaoying Wang,Yong-Sheng Xiao,Yang Xu,Yi-Wei Li,Zhao-You Tang +8 more
TL;DR: Tregs are associated with HCC invasiveness, and intratumoral balance of regulatory and cytotoxic T cells is a promising independent predictor for recurrence and survival in HCC.
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Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma.
Qiang Gao,Xiaoying Wang,Shuang-Jian Qiu,Ichiro Yamato,Masayuki Sho,Yoshiyuki Nakajima,Jian Zhou,Bai-Zhou Li,Ying-Hong Shi,Yong-Sheng Xiao,Yang Xu,Jia Fan +11 more
TL;DR: The data suggest for the first time that PD-L1 status may be a new predictor of recurrence for HCC patients and provide the rationale for developing a novel therapy of targeting the PD- L1/PD-1 pathway against this fatal malignancy.
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Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma.
Zhen-Bin Ding,Ying-Hong Shi,Jian Zhou,Shuang-Jian Qiu,Yang Xu,Zhi Dai,Guo-Ming Shi,Xiaoying Wang,Ai-Wu Ke,Bin Wu,Jia Fan +10 more
TL;DR: Exposure of autophagic genes and their corresponding autophile activities were suppressed in HCC, suggesting that the autophagy defects synergized with altered apoptotic activity might facilitate tumor malignant differentiation, which results in a more aggressive cancer cell phenotype and poor prognosis of HCC.
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High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma.
Xin-Rong Yang,Yang Xu,Bin Yu,Jian Zhou,Shuang-Jian Qiu,Guo-Ming Shi,Bo-Heng Zhang,Wei-Zhong Wu,Ying-Hong Shi,Bin Wu,Guo-Huan Yang,Yuan Ji,Jia Fan +12 more
TL;DR: The simplified model based on the HSC/HPC and tumour angiogenesis profile can be used to classify patients with HCC with a high risk of tumour recurrence after surgery.
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Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance
TL;DR: The efficacy of circulating tumor cell (CTC) detection among patients with solid malignancy has been investigated, which shows great potential to become a tool for real-time parameter of prognosis and serve as an early marker to assess the therapeutic response in overt cancers.