Y
Yang Yang
Researcher at Northwest University (China)
Publications - 5
Citations - 293
Yang Yang is an academic researcher from Northwest University (China). The author has contributed to research in topics: Reperfusion injury & Oxidative stress. The author has an hindex of 5, co-authored 5 publications receiving 236 citations. Previous affiliations of Yang Yang include Nanjing University & Fourth Military Medical University.
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Journal ArticleDOI
Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation
Liming Yu,Wen-cheng Di,Xue Dong,Zhi Li,Yong Zhang,Xiaodong Xue,Yinli Xu,Jian Zhang,Xiong Xiao,Jinsong Han,Yu Liu,Yang Yang,Yang Yang,Huishan Wang +13 more
TL;DR: Melatonin ameliorated diabetic MI/R injury by modulating Nrf-2-HO-1 and MAPK signaling, thus reducing myocardial apoptosis and oxidative stress and preserving cardiac function, and melatonin membrane receptors (especially MT2 receptor)-dependent cGMP-PKGIα signaling played a critical role in this process.
Journal ArticleDOI
Diallyl trisulfide ameliorates myocardial ischemia–reperfusion injury by reducing oxidative stress and endoplasmic reticulum stress-mediated apoptosis in type 1 diabetic rats: role of SIRT1 activation
Liming Yu,Shu Li,Xinlong Tang,Zhi Li,Jian Zhang,Xiaodong Xue,Jinsong Han,Yu Liu,Yuji Zhang,Yong Zhang,Yinli Xu,Yang Yang,Yang Yang,Yang Yang,Huishan Wang +14 more
TL;DR: Perioperative DATS treatment effectively ameliorates MI/R injury in type 1 diabetic setting by enhancing cardiac SIRT1 signaling, thus reducing myocardial apoptosis and eventually preserving cardiac function.
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Melatonin rescues cardiac thioredoxin system during ischemia-reperfusion injury in acute hyperglycemic state by restoring Notch1/Hes1/Akt signaling in a membrane receptor-dependent manner.
Liming Yu,Chongxi Fan,Zhi Li,Jian Zhang,Xiaodong Xue,Yinli Xu,Guolong Zhao,Yang Yang,Yang Yang,Huishan Wang +9 more
TL;DR: Melatonin treatment effectively ameliorated MI/R injury by reducing infarct size, myocardial apoptosis, and oxidative stress and its role as a prophylactic/therapeutic drug deserves further clinical study.
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Polydatin Protects Diabetic Heart against Ischemia-Reperfusion Injury via Notch1/Hes1-Mediated Activation of Pten/Akt Signaling.
Liming Yu,Zhi Li,Xue Dong,Xiaodong Xue,Yu Liu,Shu Xu,Jian Zhang,Jinsong Han,Yang Yang,Huishan Wang +9 more
TL;DR: Polydatin effectively reduced MI/R injury and improved left ventricular functional recovery under diabetic condition by ameliorating oxidative/nitrative stress damage.
Journal ArticleDOI
Diallyl trisulfide exerts cardioprotection against myocardial ischemia-reperfusion injury in diabetic state, role of AMPK-mediated AKT/GSK-3β/HIF-1α activation
Liming Yu,Wencheng Di,Xue Dong,Zhi Li,Xiaodong Xue,Jian Zhang,Qi Wang,Xiong Xiao,Jinsong Han,Yang Yang,Huishan Wang +10 more
TL;DR: Data showed that DATS protected against MI/R injury in diabetic state by attenuating cellular apoptosis via AMPK-mediated AKT/GSK-3β/HIF-1α signaling and its cardioprotective effect deserves further study.