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Yannick Hommet
Researcher at University of Caen Lower Normandy
Publications - 4
Citations - 126
Yannick Hommet is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Biological activity & Sp3 transcription factor. The author has an hindex of 2, co-authored 4 publications receiving 118 citations. Previous affiliations of Yannick Hommet include Centre national de la recherche scientifique.
Papers
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Journal ArticleDOI
Sp1 and Smad transcription factors co-operate to mediate TGF-β-dependent activation of amyloid-β precursor protein gene transcription
Fabian Docagne,Cecilia Gabriel,Nathalie Lebeurrier,Sylvain Lesné,Yannick Hommet,Laurent Plawinski,Eric T. MacKenzie,Denis Vivien +7 more
TL;DR: The results provide additional evidence for a key role for TGF-beta in the regulation of Abeta production and give new insights for a better understanding of the fine molecular mechanisms occurring at the transcriptional level and regulating T GF-beta-dependent transcription.
Journal ArticleDOI
Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.
Pascale Schumann,Valérie Collot,Yannick Hommet,Willy Gsell,François Dauphin,Jana Sopkova,Eric T. MacKenzie,Dominique Duval,Michel Boulouard,Sylvain Rault +9 more
TL;DR: The synthesis and pharmacological evaluation of methoxyindazoles as new inhibitors of neuronal nitric oxide synthase are presented and it is shown that the nitro-substitution is not indispensable to the biological activity of the indazole ring.
Journal ArticleDOI
Inhibition of Neuronal Nitric Oxide Synthase by 7‐Methoxyindazole and Related Substituted Indazoles.
Pascale Schumann,Valérie Collot,Yannick Hommet,Willy Gsell,François Dauphin,Jana Sopkova,Eric T. MacKenzie,Dominique Duval,Michel Boulouard,Sylvain Rault +9 more
TL;DR: In this paper, the synthesis and pharmacological evaluation of methoxyindazoles as new inhibitors of neuronal nitric oxide synthase are presented, and the 7-methoxy-indazole, although less potent than 7-NI, is the most active compound of the series in an in vitro enzymatic assay of neuronal NOS activity.
Patent
Treatment of neurological of neurodegenerative disorder
Karl-Uwe Petersen,Denis Vivien,Carine Ali,José Lopez Atalaya,Benoit D. Roussel,Yannick Hommet +5 more
TL;DR: The use of a protein or peptide for the manufacture of a medicament for the treatment of neurological or neurodegenerative disorders, in particular stroke, is discussed in this paper.