Yantao Fan

TL;DR: A novel three-dimensional (3D) brain cancer chip composed of photo-polymerizable poly(ethylene) glycol diacrylate (PEGDA) hydrogel for drug screening and commercially promising for other clinical applications, including 3D cell culture and micro-scale tissue engineering.

TL;DR: The ability to rapidly synthesize tissue volumes of varying scale to examine how tissue volume governs neuron development is used, and a simple, inexpensive, yet extremely precise method to create tissue architectures in a digitally specifiable fashion, with morphological and compositional tuning is described.

TL;DR: A novel 3-D GBM cell culture model based on microwells that could mimic in vitro environment and help to bypass the lack of suitable animal models for preclinical toxicity tests is designed and could help to reduce the time of the preclinical brain tumor growth studies.

TL;DR: An improved brain cancer chip with a diffusion prevention mechanism that blocks drugs crossing from one channel to another is developed and it is demonstrated that the chip has the ability to culture 3D spheroids from patient tumor specimen-derived GBM cells obtained from three GBM patients.

TL;DR: This work presents a simple two-step photolithography method to efficiently capture single cells in microscale gelatin methacrylate hydrogel rings and demonstrated that neural axons grew and consequently formed axonal circles, indicating that this method could be an enabling tool to analyze axonal development and autapse formation.