Y
Yao Lu
Researcher at Vaccine and Infectious Disease Organization
Publications - 11
Citations - 212
Yao Lu is an academic researcher from Vaccine and Infectious Disease Organization. The author has contributed to research in topics: Virus & Influenza A virus subtype H5N1. The author has an hindex of 5, co-authored 11 publications receiving 107 citations. Previous affiliations of Yao Lu include Western University College of Veterinary Medicine & University of Saskatchewan.
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Journal ArticleDOI
Nuclear-resident RIG-I senses viral replication inducing antiviral immunity
GuanQun Liu,GuanQun Liu,Yao Lu,Yao Lu,Sathya N. Thulasi Raman,Fang Xu,Qi Wu,Qi Wu,Zhubing Li,Zhubing Li,Robert Brownlie,Qiang Liu,Qiang Liu,Qiang Liu,Yan Zhou,Yan Zhou,Yan Zhou +16 more
TL;DR: The authors identify nuclear RIG-I and show that it binds nuclear influenza A virus RNA, resulting in a cooperative interferon induction along with its cytoplasmic counterpart, refine the RNA sensing paradigm for nuclear-replicating viruses and reveal a previously unrecognized subcellular milieu for Rig-I-like receptor sensing.
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SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney.
Magen Ellen Francis,Magen Ellen Francis,Una Goncin,Andrea Kroeker,Cynthia Swan,Robyn Ralph,Robyn Ralph,Yao Lu,Athema L. Etzioni,Darryl Falzarano,Darryl Falzarano,Volker Gerdts,Steven Machtaler,Jason Kindrachuk,Jason Kindrachuk,Alyson A. Kelvin +15 more
TL;DR: This article investigated the host responses associated with infection in several major organ systems including the respiratory tract, the heart, and the kidneys after SARS-CoV-2 infection in Syrian hamsters.
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The NS1 Protein of Influenza A Virus Participates in Necroptosis by Interacting with MLKL and Increasing Its Oligomerization and Membrane Translocation.
TL;DR: It is reported that influenza A virus (IAV) infection induces necroptosis in macrophages and epithelial cells and it is demonstrated that the NS1 protein of IAV interacts with MLKL, resulting in increasedMLKL oligomerization and membrane translocation.
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Inhibition of Ongoing Influenza A Virus Replication Reveals Different Mechanisms of RIG-I Activation.
TL;DR: RIG-I activation in response to NP deprivation is not adversely affected by expression of the nuclear export protein (NEP), which diminishes the generation of a major subset of aberrant viral RNA but facilitates the accumulation of small viral RNA (svRNA).
Journal ArticleDOI
In Vivo Characterization of Avian Influenza A (H5N1) and (H7N9) Viruses Isolated from Canadian Travelers.
Yao Lu,Shelby Landreth,Shelby Landreth,Amit Gaba,Magda Hlasny,GuanQun Liu,GuanQun Liu,Yanyun Huang,Yan Zhou,Yan Zhou,Yan Zhou +10 more
TL;DR: This study characterized the pathogenicity of AB14 (H5N1) and BC15 (H7N9) and found that both strain isolates are highly lethal in mice, providing experimental evidence to complement the specific human case reports and animal models for evaluating vaccine and antiviral candidates against potential influenza pandemics.