Yao Yu Ning

TL;DR: MARCO−/− mice treated with the “inert” environmental particle TiO2 showed enhanced inflammation and chemokine expression, indicating that MARCO-mediated clearance of inert particles by AMs prevents inflammatory responses otherwise initiated by other lung cells.

TL;DR: A dominant role for MARCO is found in the human AM defense against inhaled particles and pathogens and specifically inhibited particle binding by COS cells, only after transfection with human MARCO cDNA.

TL;DR: The results suggest that indoor-generated particles may be more bioactive than ambient particles, and the presence of other proinflammatory components of fine particles, particularly for indoor- generated particles is suggested.

TL;DR: The data suggest that metal components adsorbed to urban air pollution particulates can significantly contribute to particulate ability to cause oxidant stress and cytokine production in AMs.

TL;DR: Premating treatment with neutralizing anti-IL-4 Ab or reduction of maternal allergen exposure abrogated the maternal effect, showing a critical mechanistic role for IL-4 and suggesting an additional benefit of allerGEN avoidance.