다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Future cell-based therapies such as tissue engineering will benefit from a source of autologous pluripotent stem cells. For mesodermal tissue engineering, one such source of cells is the bone marrow stroma. The bone marrow compartment contains several cell populations, including mesenchymal stem cells (MSCs) that are capable of differentiating into adipogenic, osteogenic, chondrogenic, and myogenic cells. However, autologous bone marrow procurement has potential limitations. An alternate source of autologous adult stem cells that is obtainable in large quantities, under local anesthesia, with minimal discomfort would be advantageous. In this study, we determined if a population of stem cells could be isolated from human adipose tissue. Human adipose tissue, obtained by suction-assisted lipectomy (i.e., liposuction), was processed to obtain a fibroblast-like population of cells or a processed lipoaspirate (PLA). These PLA cells can be maintained in vitro for extended periods with stable population doubling and low levels of senescence. Immunofluorescence and flow cytometry show that the majority of PLA cells are of mesodermal or mesenchymal origin with low levels of contaminating pericytes, endothelial cells, and smooth muscle cells. Finally, PLA cells differentiate in vitro into adipogenic, chondrogenic, myogenic, and osteogenic cells in the presence of lineage-specific induction factors. In conclusion, the data support the hypothesis that a human lipoaspirate contains multipotent cells and may represent an alternative stem cell source to bone marrow-derived MSCs.

/pdf/multilineage-cells-from-human-adipose-tissue-implications-4z32vwpf0q.pdf

Multilineage cells from human adipose tissue: implications for cell-based therapies.

https://www.researchgate.net/file.PostFileLoader.html?id=526892a1d4c118a61d4360bd&assetKey=AS%3A272155479085058%401441898330516

Porosity of 3D biomaterial scaffolds and osteogenesis.

Hydrogels for tissue engineering: scaffold design variables and applications.

症例犬2頭の褥瘡部位に早期閉鎖と上皮化を目的として徐放化bFGFハイドロゲルを投与した。徐放化bFGFハイドロゲル投与後7日目の2頭の平均創縮小率は39.4±8.80％と顕著に認められた。肉芽形成は両症例において徐放化bFGFハイドロゲル投与後3～14日目に赤色の健康肉芽形成を認め，以降，表皮形成を認めた。また，全ての症例は徐放化bFGFハイドロゲル投与後28日目に創の閉鎖を認め，その後，再発を認めなかった。以上のことから犬の褥創に対して，徐放化bFGFハイドロゲルの単回投与を行うことで，今まで閉鎖まで時間を要した褥瘡の治癒促進を行うことが可能であると考えた。

https://www.jstage.jst.go.jp/article/jjvd/17/3/17_3_161/_pdf

Basic Fibroblast Growth Factor (bFGF) Incorporating Gelatin Hydrogel Accelerates Wound Healing in Refractory Ulcers in the 2 Dogs

A vitreous body visualization agent which is to be injected into the eye to visualize the vitreous body by a safe and sure method. The vitreous body visualization agent is prepared by using a polymeric substance having positively or negatively charged functional groups and adding a hardly water-soluble and non-steroidal colored substance, in which the polymeric substance is to be suspended, thereto. Due to having a non-steroidal nature, it can be safely injected into the eye, and the colored substance, in which the polymeric substance is to be suspended, makes the vitreous body visually recognizable.

Agent for visualizing vitreous body

Although interferon (IFN) α and β are currently recognized as the most effective agents for treating patients with chronic hepatitis B and C, they are well known to cause various adverse effects. To reduce the dose of IFN necessary for treatment, we tried enhancing the effects of IFN in the liver by ultrasound exposure. Percutaneous insonation in mouse liver following IFN- β injection with the ultrasound power level used at clinical diagnosis enhanced the IFN- β -induced increase of 2',5'-oligoadenylate synthetase (2-5AS) levels in the liver. This enhancement of the 2-5AS level was dependent on the duration as well as on the timing of insonation after the IFN- β injection. In contrast, liver insonation did not enhance 2-5AS levels in the lung or spleen, and moreover, it did not alter tissue distribution of injected IFN. Thus, the combination of IFN- β administration and subsequent liver insonation appears to be a promising method for enhancing the antiviral activity of IFN specifically in the liver, enabl...

/pdf/ultrasound-exposure-enhances-the-biological-action-of-21516ekaqz.pdf

Ultrasound Exposure Enhances the Biological Action of Interferon in the Liver

The Editor-in-Chief has retracted this article [1] at the request of the corresponding author. Figure 1B appears to be identical to Figure 1D, despite being under different experimental conditions.

/pdf/retraction-note-in-vitro-transfection-of-plasmid-dna-by-2jfpkwafaq.pdf

Retraction Note: In Vitro Transfection of Plasmid DNA by Amine Derivatives of Gelatin Accompanied with Ultrasound Irradiation.

It is intended to provide a base material for reconstructing a tissue or an organ which is highly biocompatible and shows regulated graft contraction. Namely, a base material for reconstructing a tissue or an organ which contains a cell-free tissue matrix and a cell growth factor.

Yasuhiko Tabata

Papers

Basic Fibroblast Growth Factor (bFGF) Incorporating Gelatin Hydrogel Accelerates Wound Healing in Refractory Ulcers in the 2 Dogs

Agent for visualizing vitreous body

Ultrasound Exposure Enhances the Biological Action of Interferon in the Liver

Retraction Note: In Vitro Transfection of Plasmid DNA by Amine Derivatives of Gelatin Accompanied with Ultrasound Irradiation.

Base material for reconstructing tissue or organ containing cell-free tissue matrix and cell growth factor