Y
Yasuhiro Uno
Researcher at Central Institute for Experimental Animals
Publications - 152
Citations - 2391
Yasuhiro Uno is an academic researcher from Central Institute for Experimental Animals. The author has contributed to research in topics: Marmoset & Cytochrome P450. The author has an hindex of 25, co-authored 138 publications receiving 2112 citations. Previous affiliations of Yasuhiro Uno include University of Tokyo & Vanderbilt University.
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Journal ArticleDOI
CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone.
TL;DR: It is suggested that CYP2C76 contributes to overall drug-metabolizing activity in the monkey liver and might account for species difference occasionally seen in drug metabolism between monkeys and humans.
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Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function.
TL;DR: An overview of the identity and functional characteristics of each P450 cDNA in the CYP1-4 families is presented and a revised nomenclature is proposed to promote a better understanding of monkey P450 genes through comparative genomics and thereby make it more feasible to use monkeys in drug metabolism studies.
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Natural selection in the TLR- related genes in the course of primate evolution
Toshiaki Nakajima,Hitoshi Ohtani,Yoko Satta,Yasuhiro Uno,Hirofumi Akari,Takafumi Ishida,Akinori Kimura +6 more
TL;DR: Evidence is provided that the TLR-related genes have come under natural selection pressure in the course of primate evolution, and the genomic segments encoding the intracellular Toll/interleukin 1 receptor domains, which exhibited lower rates of non-synonymous substitution, have undergone purifying selection.
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Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism?
Yasuhiro Uno,Shinya Hosaka,Kiyomi Matsuno,Chika Nakamura,Go Kito,Tetsuya Kamataki,Ryoichi Nagata +6 more
TL;DR: Results suggest that these 11 monkey CYP cDNAs are closely related to the human CYPcDNAs and thus, unlike CYP2C76, are not apparent monkey-specific c DNAs.
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Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta
TL;DR: The mosaic pattern of species divergence in the genomes may be a consequence of genetic differentiation under ecological adaptation and May be a salient feature in the genome of nascent species under parapatry.