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Showing papers by "Yasushi Shintani published in 2007"

Journal Article•DOI•
Therapeutic time window of post-ischemic mild hypothermia and the gene expression associated with the neuroprotection in rat focal cerebral ischemia.

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Hiroyuki Ohta1, Yasuko Terao1, Yasushi Shintani1, Yoshihiro Kiyota1•
Takeda Pharmaceutical Company1
01 Mar 2007-Neuroscience Research
TL;DR: It was concluded that the therapeutic time window of mild hypothermia lasts for 4h after reperfusion in the authors' model, and the neuroprotective effects of post-ischemic mild hypotherapy were strongly suggested to be mainly associated with the reduction of neuronal inflammation.

103 citations

Patent•
Use of a G protein-coupled receptor and its cognizant ligand in the identification of compounds that affect prolactin secretion

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Takuya Watanabe1, Kuniko Kikuchi1, Yasuko Terao1, Yasushi Shintani1, Shuji Hinuma1, Shoji Fukusumi1, Ryo Fujii1, Masaki Hosoya1, Chieko Kitada1 •
Takeda Pharmaceutical Company1
02 Feb 2007
TL;DR: The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of Prolactin secretion stimulants, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc as mentioned in this paper.
Abstract: The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

1 citations

Patent•
Screening assay using G-protein coupled receptor protein OT7T175

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Takuya Watanabe1, Yasuko Terao1, Yasushi Shintani1, Tetsuya Ohtaki1, Kimiko Kanehashi1, Chieko Kitada1 •
Takeda Pharmaceutical Company1
24 Oct 2007
TL;DR: In this article, a method/kit for screening compounds that alter the binding property between the ligands and the GPCR proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.
Abstract: The present invention relates to rat cerebellum-derived and human brain-derived G protein coupled receptor proteins or salts thereof, their partial peptides, amides, esters or salts thereof, ligands to the same, a method/kit for screening compounds that alter the binding property between the ligands and the G protein coupled receptor proteins, compounds obtained by the screening or salts thereof, and antibodies to the G protein coupled receptor proteins.