Yatin R. Gokarn

TL;DR: It is shown that presentation of antibodies on the surface of nonspherical particles enhances antibody specificity as well as avidity toward their targets, opening unique opportunities for particulate forms of antibodies in therapeutics and diagnostics.

TL;DR: This Review summarizes the current status, latest updates and future prospects for delivery of peptides, proteins and other biologics, including subcutaneous, transdermal, oral, inhalation, nasal and buccal routes.

TL;DR: Improvements in analytical techniques such as protein mass spectrometry and capillary electrophoresis have significantly increased the quality of information that can be obtained for use in product and process characterization, and for routine lot release and stability testing.

TL;DR: The results provide compelling evidence in support of weak intermolecular interactions, in contrast to the notion that the electroviscous effect is important in governing the viscoelastic behavior of concentrated mAb solutions.

TL;DR: The analyses of SANS patterns as a function of different solution conditions suggest that the average intramolecular structure of both MAbs in solution is not significantly altered over the studied protein concentrations and experimental conditions.