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Yehia Daaka
Researcher at University of Florida
Publications - 98
Citations - 11639
Yehia Daaka is an academic researcher from University of Florida. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 46, co-authored 94 publications receiving 11222 citations. Previous affiliations of Yehia Daaka include Howard Hughes Medical Institute & Georgia Regents University.
Papers
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Journal ArticleDOI
Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.
Yehia Daaka,Julie A. Pitcher,Mark Richardson,Robert H. Stoffel,Janet D. Robishaw,Robert J. Lefkowitz +5 more
TL;DR: This study provides a direct demonstration of a role for G betagamma in mediating the agonist-stimulated translocation of GRK2 and GRK3 in an intact cellular system and demonstrates isoform specificity in the interaction of these components.
Book ChapterDOI
Mechanisms of beta-adrenergic receptor desensitization and resensitization.
TL;DR: The phosphatases and regulatory mechanisms involved in this resensitization process have only recently begun to be elucidated and are included in this chapter.
Journal ArticleDOI
beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor.
TL;DR: An expanded role of β-arrestins is reported in promoting clathrin-mediated endocytosis of a tyrosine kinase growth factor receptor, i.e. the insulin-like growth factor I (IGF-1) receptor.
Journal ArticleDOI
Nitric oxide regulates endocytosis by S-nitrosylation of dynamin
TL;DR: A general NO-dependent mechanism by which the trafficking of receptors may be regulated is suggested and the idea that pathogenic microbes and viruses may induce S-nitrosylation of dynamin to facilitate cellular entry is raised.
Journal ArticleDOI
The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin
Julie A. Pitcher,Randy A. Hall,Yehia Daaka,Jie Zhang,Stephen S. G. Ferguson,Susan Hester,Sara E. Miller,Marc G. Caron,Robert J. Lefkowitz,Larry S. Barak +9 more
TL;DR: A novel role for GRK2 is suggested as a GPCR signal transducer mediating the effects of GPCRs activation on the cytoskeleton and phosphorylation of tubulin is identified.