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Yeong-Shiau Pu
Researcher at National Taiwan University
Publications - 268
Citations - 9387
Yeong-Shiau Pu is an academic researcher from National Taiwan University. The author has contributed to research in topics: Prostate cancer & Bladder cancer. The author has an hindex of 40, co-authored 254 publications receiving 8465 citations. Previous affiliations of Yeong-Shiau Pu include National Institutes of Health & Taipei Medical University.
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Journal Article
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
Ann-Lii Cheng,Hsu Ch,Lin Jk,Hsu Mm,Yunn-Fang Ho,Shen Ts,Ko Jy,Lin Jt,Bor-Ru Lin,Ming-Shiang W,Yu Hs,Shiou-Hwa Jee,Chen Gs,Chen Tm,Chi-An Chen,Lai Mk,Yeong-Shiau Pu,Min-Hsiung Pan,Wang Yj,Tsai Cc,Hsieh Cy +20 more
TL;DR: It is demonstrated that curcumin is not toxic to humans up to 8,000 mg/day when taken by mouth for 3 months and a biologic effect ofCurcumin in the chemoprevention of cancer is suggested.
Journal Article
Incidence of Internal Cancers and Ingested Inorganic Arsenic: A Seven-Year Follow-up Study in Taiwan
Hung Yi Chiou,Yu Mei Hsueh,Kuen Fu Liaw,Shan Far Horng,Ming Hsi Chiang,Yeong-Shiau Pu,Johnny Shinn Nan Lin,Chun Hsiung Huang,Chien-Jen Chen,Chien-Jen Chen +9 more
TL;DR: A dose-response relationship was observed between the long-term arsenic exposure from drinking artesian well water and the incidence of lung cancer, bladder cancer, and cancers of all sites combined after adjustment for age, sex, and cigarette smoking through Cox's proportional hazards regression analysis.
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Aristolochic acid-associated urothelial cancer in Taiwan
Chung-Hsin Chen,Kathleen G. Dickman,Masaaki Moriya,Jiri Zavadil,Viktoriya S. Sidorenko,Karen L. Edwards,Dmitri V. Gnatenko,Lin Wu,Robert J. Turesky,Xue-Ru Wu,Yeong-Shiau Pu,Arthur P. Grollman +11 more
TL;DR: It is concluded that exposure to aristolochic acid contributes significantly to the incidence of UUC in Taiwan, a finding with significant implications for global public health.
Journal ArticleDOI
Resistance to Paclitaxel Is Proportional to Cellular Total Antioxidant Capacity
Balakrishnan Ramanathan,K.Y. Jan,Chien-Hung Chen,Tzyh-Chyuan Hour,Hong-Jen Yu,Yeong-Shiau Pu +5 more
TL;DR: The results suggest that paclitaxel chemosensitivity may be predicted by taking total antioxidant capacity measurements from clinical tumor samples, which may then improve treatment outcomes by selecting out potentially responsive patients.
Journal ArticleDOI
Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing
Margaret L. Hoang,Chung-Hsin Chen,Viktoriya S. Sidorenko,Jian He,Kathleen G. Dickman,Byeong Hwa Yun,Masaaki Moriya,Noushin Niknafs,Christopher Douville,Rachel Karchin,Robert J. Turesky,Yeong-Shiau Pu,Bert Vogelstein,Nickolas Papadopoulos,Arthur P. Grollman,Kenneth W. Kinzler,Thomas A. Rosenquist +16 more
TL;DR: A “molecular signature” of AA-induced DNA damage is presented, which helps to explain the mutagenic effects of AA and may also be useful as a way to detect unsuspected AA exposure as a cause of cancer.