Toxicological effects of polystyrene microplastics on earthworm (Eisenia fetida)

A review of organophosphate flame retardants and plasticizers in the environment: Analysis, occurrence and risk assessment.

Microplastics could be a threat to plants in terrestrial systems directly or indirectly

Microplastic digestion generates fragmented nanoplastics in soils and damages earthworm spermatogenesis and coelomocyte viability.

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Office of Environmental Health Hazard Assessment

Intestinal damage, neurotoxicity and biochemical responses caused by tris (2-chloroethyl) phosphate and tricresyl phosphate on earthworm.

Triphenyl phosphate exposure induces kidney structural damage and gut microbiota disorders in mice under different diets

Organophosphate flame retardants (OPFRs) have become a growing concern due to their potential environmental and health risk. However, limited studies have described the toxicity, particularly neurotoxicity of alkyl and aromatic OPFRs. This study investigated the neurotoxicity of alkyl tri-n-butyl phosphate (TnBP) and aromatic tricresyl phosphate (TCP) to rat adrenal pheochromocytoma (PC12) cells for 24 h. Viability detection showed dose-response toxicity effect of TCP and TnBP to PC12 cells. The half-maximal inhibitory concentration of 24 h (24 h-IC50 ) of TCP and TnBP were 2415.61 and 338.09 μM, respectively. Both TnBP and TCP significantly changed the acetylcholinesterase (AChE) activity, and TnBP is more likely to cause neurotoxicity to PC12 cells compared to TCP. Also, The results of LDH and caspase-3 activity detection as well as Hoechst staining suggested that cell apoptosis induced by TCP and TnBP may be the primary pathway. These findings provide a toxicity data of aromatic and alkyl-substituted OPFRs to PC12 cells, and a new insight into the toxicity of OPFRs on health risk assessment.

Yeqian Chang

Papers

Toxicological effects of polystyrene microplastics on earthworm (Eisenia fetida)

Intestinal damage, neurotoxicity and biochemical responses caused by tris (2-chloroethyl) phosphate and tricresyl phosphate on earthworm.

Triphenyl phosphate exposure induces kidney structural damage and gut microbiota disorders in mice under different diets

Comparative assessment of neurotoxicity impacts induced by alkyl tri-n-butyl phosphate and aromatic tricresyl phosphate in PC12 cells.

Liver immune and lipid metabolism disorders in mice induced by triphenyl phosphate with or without high fructose and high fat diet.