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Yi-Bing Ouyang
Researcher at Stanford University
Publications - 49
Citations - 3222
Yi-Bing Ouyang is an academic researcher from Stanford University. The author has contributed to research in topics: Astrocyte & Mitochondrion. The author has an hindex of 27, co-authored 46 publications receiving 2884 citations.
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Journal ArticleDOI
Astrocytes: targets for neuroprotection in stroke.
TL;DR: This review will focus on those functions of astrocytes that can both protect and endanger neurons, and discuss how manipulating these functions provides a novel and important strategy to enhance neuronal survival and improve outcome following cerebral ischemia.
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Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia.
TL;DR: It is suggested that greater oxidative stress and loss of GLT-1 function selectively in CA1 astrocytes is central to the well known delayed death of CA1 neurons.
Journal ArticleDOI
miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes.
TL;DR: Decreased miR-181a levels reduced glucose deprivation induced apoptosis, mitochondrial dysfunction, and loss of mitochondrial membrane potential in astrocytes.
Journal ArticleDOI
miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo
Yi-Bing Ouyang,Yu Lu,Yu Lu,Sibiao Yue,Lijun Xu,Xiaoxing Xiong,Robin E. White,Xiaoyun Sun,Rona G. Giffard +8 more
TL;DR: It is demonstrated that miR-181 levels change in response to stroke and inversely correlate with levels of GRP78, which protects the brain from stroke.
Journal ArticleDOI
Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.
Rona G. Giffard,Lijun Xu,Heng Zhao,Whitney Carrico,Yi-Bing Ouyang,Yanli Qiao,Robert M. Sapolsky,Gary K. Steinberg,Bingren Hu,Midori A. Yenari +9 more
TL;DR: It is demonstrated that overexpression of Hsp70 in hippocampal CA1 neurons reduces evidence of protein aggregation under conditions where neuronal survival is increased, and protection by the cochaperone Hdj-2 in vitro and this is associated with reduced protein aggregation identified by ubiquitin immunostaining.