Y
Yi Hsiao
Researcher at Bristol-Myers Squibb
Publications - 58
Citations - 2674
Yi Hsiao is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 25, co-authored 57 publications receiving 2419 citations. Previous affiliations of Yi Hsiao include Merck & Co. & Nagoya University.
Papers
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Journal ArticleDOI
Highly Efficient Asymmetric Synthesis of Sitagliptin
Karl B. Hansen,Yi Hsiao,Feng Xu,Nelo R. Rivera,Andrew M. Clausen,Michele Kubryk,Shane W. Krska,Thorsten Rosner,Bryon Simmons,Jaume Balsells,Nori Ikemoto,Yongkui Sun,Felix Spindler,Christophe Malan,Edward J. J. Grabowski,Joseph D. Armstrong +15 more
TL;DR: This environmentally friendly, 'green' synthesis significantly reduces the total waste generated per kilogram of sitagliptin produced in comparison with the first-generation route and completely eliminates aqueous waste streams.
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Asymmetric synthesis of isoquinoline alkaloids by homogeneous catalysis
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Highly Efficient Synthesis of β-Amino Acid Derivatives via Asymmetric Hydrogenation of Unprotected Enamines
Yi Hsiao,Nelo R. Rivera,Thorsten Rosner,Shane W. Krska,Eugenia Njolito,Fang Wang,Yongkui Sun,Joseph D. Armstrong,Edward J. J. Grabowski,Richard D. Tillyer,Felix Spindler,Christophe Malan +11 more
TL;DR: A direct asymmetric hydrogenation of unprotected enamino esters and amides is described, catalyzed by Rh complexes with Josiphos-type chiral ligands, which gives beta-amino amides in high yield and high ee.
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Catalytic Production of Dimethylformamide from Supercritical Carbon Dioxide
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First Generation Process for the Preparation of the DPP-IV Inhibitor Sitagliptin
Karl B. Hansen,Jaume Balsells,Spencer D. Dreher,Yi Hsiao,Michele Kubryk,Michael Palucki,Nelo R. Rivera,Dietrich Steinhuebel,Joseph D. Armstrong,David Askin,Edward J. J. Grabowski +10 more
TL;DR: In this paper, a new synthesis of sitagliptin (MK-0431), a DPP-IV inhibitor and potential new treatment for type II diabetes, suitable for the preparation of multi-kilogram quantities is presented.