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Yi Ru
Researcher at Fourth Military Medical University
Publications - 33
Citations - 255
Yi Ru is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 8, co-authored 16 publications receiving 166 citations.
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Journal ArticleDOI
GOLM1 promotes prostate cancer progression through activating PI3K-AKT-mTOR signaling.
Guang Yan,Yi Ru,Kerong Wu,Fengqi Yan,Qinhao Wang,Jingxiang Wang,Tao Pan,Mei Zhang,Hua Han,Xia Li,Lian Zou +10 more
TL;DR: GOLM1 has been identified as a novel biomarker for PCa, but its biological functions and molecular mechanisms remain poorly understood.
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MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway
Keshan Zhang,Bo Yang,Chaochao Shen,Ting Zhang,Yu Hao,Dajun Zhang,Huanan Liu,Xijuan Shi,Guoli Li,Jinke Yang,Dan Li,Zixiang Zhu,Hong Tian,Fan Yang,Yi Ru,Weijun Cao,Jianhong Guo,Jijun He,Haixue Zheng,Xiangtao Liu +19 more
TL;DR: The results showed that MGF360-9L may help ASFV escape the host immunity by degrading STAT1 and STAT2 and thus inhibiting IFN-β signaling and is also an important virulence factor of AsFV.
Journal ArticleDOI
Transcription factor Nrf1 is negatively regulated by its O-GlcNAcylation status
Jiayu Chen,Jiayu Chen,Xiping Liu,Xiping Liu,Fenglin Lü,Xinping Liu,Yi Ru,Yonggang Ren,Libo Yao,Yiguo Zhang +9 more
TL;DR: It is shown that Nrf1 enables interaction with OGT and their co‐immunoprecipitates are O‐GlcNAcylated by the enzyme, which negatively regulates NRF1/TCF11 to reduce both its protein stability and transactivation activity of target gene expression.
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The chimeric ubiquitin ligase SH2-U-box inhibits the growth of imatinib-sensitive and resistant CML by targeting the native and T315I-mutant BCR-ABL
Yi Ru,Qinhao Wang,Xiping Liu,Xiping Liu,Mei Zhang,Daixing Zhong,Mingxiang Ye,Yuanchun Li,Hua Han,Libo Yao,Xia Li +10 more
TL;DR: By degrading the native and T315I-mutant BCR-ABL, the chimeric ubiquitin ligase SH2-U-box may serve as a potential therapy for both imatinib-sensitive and resistant CML.
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NDRG2 overexpression suppresses hepatoma cells survival during metabolic stress through disturbing the activation of fatty acid oxidation
Tao Pan,Mei Zhang,Fang Zhang,Guang Yan,Yi Ru,Qinhao Wang,Yao Zhang,Xuehui Wei,Xinyuan Xu,Lan Shen,Jian Zhang,Kaichun Wu,Libo Yao,Xia Li +13 more
TL;DR: As a negative regulator of AMPK, NDRG2 disturbs the induction of FAO genes by glucose limitation, leading to dysregulation of ATP and NADPH, and thus reduces the tolerance of hepatoma cells to glucose limitation.