Yigang Tong

TL;DR: The discovery of multiple lineages of pangolin coronavirus and their similarity to SARS-CoV-2 suggests that pangolins should be considered as possible hosts in the emergence of new coronaviruses and should be removed from wet markets to prevent zoonotic transmission.

TL;DR: The study suggests that inhibition of NF-κB-mediated BACE1 expression may be a valuable drug target for AD therapy, and indicates that NSAIDs could block the inflammation-induced Bace1 transcription and Aβ production.

TL;DR: A novel promoterless enhanced green fluorescent protein (EGFP) reporter gene cloning vector is generated and a 1.9-kb BACE1 gene promoter fragment can efficiently activate EGFP or luciferase gene transcription, which may contribute to the pathogenesis of Alzheimer’s disease.

TL;DR: The results strongly suggest that CEP is a wide-spectrum inhibitor of pan-betacoronavirus, and further study of CEP for treatment of 2019-nCoV infection is warranted.

TL;DR: It is demonstrated that lower BACE transcription is responsible for the minority of APP undergoing the amyloidogenic pathway and relatively lower Aβ production in the normal conditions, and that a slight increase in BACE1 can induce a dramatic elevation in A β production, indicating that the increase in FASEB can potentially increase neuritic plaque formation in the pathological condition.