Yihua Zhao

TL;DR: A genetically encoded Src reporter is developed that enables the imaging and quantification of spatio-temporal activation of Src in live cells and finds that the transmission of mechanically induced Src activation is a dynamic process that directs signals via the cytoskeleton to spatial destinations.

TL;DR: Investigation of gene expression profiles in cultured human aortic endothelial cells in response to 24 h of laminar shear stress suggests that 24-h shearing may keep ECs in a relatively noninflammatory and nonproliferative state compared with static cells.

TL;DR: A novel technique to measure the three-dimensional traction forces exerted by live bovine aortic endothelial cells on polyacrylamide deformable substrate can be applied to study live cells to assess their biomechanical dynamics in conjunction with biochemical and functional activities, for investigating cellular functions in health and disease.

TL;DR: The genetic programming and signaling of SMCs in collagen matrix as a three‐dimensional environment and on a two‐dimensional surface are compared to elucidate the molecular basis of the modulation of SMC phenotypes by the extracellular matrix.

TL;DR: The findings suggest that the cell junction remodeling induced by different flow patterns may result from a redistribution of VE-cadherin within the cell membrane.