Effects of Bacillus subtilis on carbon components and microbial functional metabolism during cow manure-straw composting.

Improving the humification and phosphorus flow during swine manure composting: A trial for enhancing the beneficial applications of hazardous biowastes

Relating bacterial dynamics and functions to gaseous emissions during composting of kitchen and garden wastes.

Effect of aeration rates on enzymatic activity and bacterial community succession during cattle manure composting

Odor emission and microbial community succession during biogas residue composting covered with a molecular membrane.

Enhanced biogas production from swine manure anaerobic digestion via in-situ formed graphene in electromethanogenesis system

Effect of biochar combined with a biotrickling filter on deodorization, nitrogen retention, and microbial community succession during chicken manure composting.

Carrier-free programmed spherical nucleic acid for effective ischemic stroke therapy via self-delivery antisense oligonucleotide

P2Y receptors (P2YRs) are G protein-coupled receptors that are activated by extracellular nucleotides. The P2Y6 receptor (P2Y6R) is specifically activated by UDP, causing PKC activation and intracellular calcium ion release through the PLC pathway. Based on receptor tissue distribution and related pathways, several studies have reported that P2Y6R plays a physiological role in mediating inflammation, which suggests that P2Y6R could be a promising molecular target for the treatment of inflammatory diseases. In the past ten years, several P2Y6R antagonists have been discovered as new therapeutic strategies for inflammatory diseases. In this article, we systematically summarize the role of P2Y6R in inflammation and highlight the anti-inflammatory mechanism of a key P2Y6R antagonist, MRS2578. Insight into recent progress on the discovery of P2Y6R antagonists are also discussed.

Yinchao Li

Papers

Odor emission and microbial community succession during biogas residue composting covered with a molecular membrane.

Enhanced biogas production from swine manure anaerobic digestion via in-situ formed graphene in electromethanogenesis system

Effect of biochar combined with a biotrickling filter on deodorization, nitrogen retention, and microbial community succession during chicken manure composting.

Carrier-free programmed spherical nucleic acid for effective ischemic stroke therapy via self-delivery antisense oligonucleotide

P2Y6R: a promising new target in inflammatory diseases and the advance of its antagonists.