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Ying-Wan Lam
Researcher at University of Chicago
Publications - 10
Citations - 490
Ying-Wan Lam is an academic researcher from University of Chicago. The author has contributed to research in topics: Thalamus & Photostimulation. The author has an hindex of 8, co-authored 10 publications receiving 449 citations.
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Journal ArticleDOI
Functional Organization of the Somatosensory Cortical Layer 6 Feedback to the Thalamus
Ying-Wan Lam,S. Murray Sherman +1 more
TL;DR: The results suggest that the top-down modulation ofThalamic neurons from cortical layer 6 involves an inhibitory component via the thalamic reticular nucleus, and this component can be selectively reduced by cholinergic input.
Journal ArticleDOI
Functional organization of the thalamic input to the thalamic reticular nucleus.
Ying-Wan Lam,S.M. Sherman +1 more
TL;DR: There is proposed to be a subpopulation of TRN neurons that receive convergent inputs from multiple thalamic sources and engage in more complex patterns of inhibition of relay cells that enable the TRN to act as an externally driven “searchlight” that integrates cortical and subcortical inputs and then inhibits or disinhibits specific thalamoreticular relay cells, so that appropriate information can get through the thalamus to the cortex.
Journal ArticleDOI
Mapping by laser photostimulation of connections between the thalamic reticular and ventral posterior lateral nuclei in the rat.
Ying-Wan Lam,S. Murray Sherman +1 more
TL;DR: Laser scanning photostimulation through a focused UV laser of caged glutamate in an in vitro slice preparation through the rat's somatosensory thalamus to study topography and connectivity between the thalamic reticular nucleus and ventral posterior lateral nucleus confirmed and extended previous observations.
Journal ArticleDOI
Mapping of the Functional Interconnections Between Thalamic Reticular Neurons Using Photostimulation
TL;DR: The results suggest that the GABAergic axodendritic synapse is the dominant form of reticulo-reticular connectivity, and because they are much weaker than the reticul-relay cell synapses, their functional purpose may be to regulate the spatial extent of the reticular inhibition on relay cells.
Journal ArticleDOI
Different topography of the reticulothalmic inputs to first- and higher-order somatosensory thalamic relays revealed using photostimulation.
Ying-Wan Lam,S. Murray Sherman +1 more
TL;DR: It is proposed that the more topographic reticular input is the basis of local inhibition seen in posterior nucleus neurons and that theMore diffuse and convergent input may represent circuitry through which the ventral posterior lateral and posterior nuclei interact.