Ying-Yu Chen

TL;DR: Alternative enterotype states are associated with long-term diet, particularly protein and animal fat (Bacteroides) versus carbohydrates (Prevotella) and other enterotypes distinguished primarily by levels of Bacteroide and Prevotella.

TL;DR: In this paper, the authors used the phenotype of RELMβ knockout mice to assess the influence of host phenotype, genotype, immune function, and diet on the composition of the human gut microbiome.

TL;DR: Recommendations for protocols to collect, process and sequence bacterial 16S rDNA from fecal samples are presented--some major points are bead-beating in hot phenol or use of the PSP kit improves recovery; storage methods can be adjusted based on experimental convenience; unweighted (presence-absence) comparisons are less affected by lysis method.

TL;DR: Gut fungal populations change radically during normal mouse husbandry, fungi grow out in the gut upon suppression of bacterial communities with antibiotics, and perturbations due to antibiotics persist long term in both the fungal and bacterial microbiota.

TL;DR: Results provide proof of concept that inoculation of a prepared host with a defined gut microbiota can lead to durable metabolic changes with therapeutic utility and in a murine model of hepatic injury, ASF transplantation was associated with decreased morbidity and mortality.