Stephanie Grunberg

TL;DR: It is shown that interleukin-22 (IL-22)–producing innate lymphoid cells (ILCs) are present in intestinal tissues of healthy mammals, indicating that ILCs regulate selective containment of lymphoid-resident bacteria to prevent systemic inflammation associated with chronic diseases.

TL;DR: A radial gradient of microbes linked to the distribution of oxygen and nutrients provided by host tissue is observed in an analysis of intestinal microbiota of mice and human beings.

TL;DR: It is identified that ILCs maintain intestinal homeostasis through MHCII-dependent interactions with CD4+ T cells that limit pathological adaptive immune cell responses to commensal bacteria.

TL;DR: Ass associations of diet with fungal and archaeal populations are investigated, taking advantage of samples from 98 well-characterized individuals, and a host of new associations to consider in modeling the effects of diet on the gut microbiome and human health are provided.

TL;DR: Re-derivation of HDAC3ΔIEC mice into germ-free conditions revealed that dysregulated IEC gene expression, Paneth cell homeostasis and intestinal barrier function were largely restored in the absence of commensal bacteria.