Showing papers by "Yong Li published in 2012"
TL;DR: In vitro experiments demonstrate that water-soluble Fe(3)O(4) NPs-DBI-PEG-NH-DTPA-AMC(7-amino-4-methyl coumarin)-Eu(3+) has excellent cell permeating activity and the relaxation rate test shows a higher T1 relaxation effect than traditional DTPA-Gd(3%) MRI agents.
Abstract: In the present study, we report new water-soluble cell fluorescence imaging and contrast agents that are based on DTPA-AMC(7-amino-4-methyl coumarin)-Eu3+ and DTPA-AMC(7-amino-4-methyl coumarin)-Gd3+ compounds conjugated to Fe3O4 NPs via a PEG-NH2 linker. The novel Fe3O4 NP-conjugates present two main advantages for cell fluorescence labelling: water solubility and targeting ability. The in vitro experiments demonstrate that water-soluble Fe3O4 NPs-DBI-PEG-NH-DTPA-AMC(7-amino-4-methyl coumarin)-Eu3+ has excellent cell permeating activity. Moreover, the relaxation rate test of Fe3O4 NPs-DBI-PEG-NH-DTPA-AMC(7-amino-4-methyl coumarin)-Gd3+ shows a higher T1 relaxation effect than traditional DTPA-Gd3+ MRI agents. According to in vivo liver MRI experiments, better contrast of the liver was achieved after addition of Fe3O4 NPs-DBI-PEG-NH-DTPA-AMC(7-amino-4-methyl coumarin)-Gd3+. The results will provide a significant guide for researchers exploring the biomedical applications of superparamagnetic Fe3O4 NPs.
24 citations
TL;DR: A Schiff base derived from two similar pyrazolone derivatives 4-(1′-phenyl-3′-methyl-5′-hydroxypyrazol-4′-yl)methyleneiminophenazone and its Tb(III and Dy(III) complexes were determined by X-ray crystal diffraction as discussed by the authors.
Abstract: A Schiff base derived from two similar pyrazolone derivatives 4-(1′-phenyl-3′-methyl-5′-hydroxypyrazol-4′-yl)methyleneiminophenazone and its Tb(III) and Dy(III) complexes were synthesized and characterized. The molecular structures of the ligand and Dy(III) complex were determined by X-ray crystal diffraction. The DNA-binding properties of the compounds were investigated by electronic absorption spectroscopy, fluorescence spectra, and viscosity measurements. The compounds interact with DNA through intercalation. The compounds also exhibit potential antioxidant activities in vitro and the antioxidant activity of the Ln(III)-complexes was stronger than that of the ligand alone and some standard antioxidants, such as mannitol and vitamin C.
19 citations