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Yong Mao
Researcher at Rutgers University
Publications - 44
Citations - 3347
Yong Mao is an academic researcher from Rutgers University. The author has contributed to research in topics: Topoisomerase & Extracellular matrix. The author has an hindex of 21, co-authored 38 publications receiving 3076 citations. Previous affiliations of Yong Mao include Princeton University & University of Medicine and Dentistry of New Jersey.
Papers
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Journal ArticleDOI
Fibronectin fibrillogenesis, a cell-mediated matrix assembly process.
Yong Mao,Jean E. Schwarzbauer +1 more
TL;DR: In this review, the main steps of fibronectin assembly are described and recent studies on fibronECTin conformational changes are discussed.
Journal ArticleDOI
Mechanism of action of camptothecin
TL;DR: Camptothecin class of compounds has been demonstrated to be effective against a broad spectrum of tumors and two novel repair responses to topo‐I‐mediated DNA damage involving covalent modifications of topo-I have been discovered.
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SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage
TL;DR: Treatment of mammalian cells or yeast cells expressing human DNA TOP1 with camptothecin (CPT) induces covalent modification of the TOP1 by SUMO-1/Smt3p, a ubiquitin-like protein.
Journal ArticleDOI
26 S proteasome-mediated degradation of topoisomerase II cleavable complexes.
TL;DR: It is shown that TOP2 cleavable complexes induced by the prototypic TOP2 poison VM-26 are proteolytically degraded by the ubiquitin/26 S proteasome pathway, and surprisingly the TOP2β isozyme is preferentially degraded over TOP2α isozyme.
Journal ArticleDOI
Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress
TL;DR: The results demonstrate a potential role of TOP2 in oxidative damage of DNA and apoptotic cell death and show the formation of reversible HMW DNA fragments is reversible and mediated by DNA topoisomerase II (TOP2).