Y
Yong S. Jong
Researcher at Brown University
Publications - 23
Citations - 2319
Yong S. Jong is an academic researcher from Brown University. The author has contributed to research in topics: Gene delivery & Immunotherapy. The author has an hindex of 18, co-authored 23 publications receiving 2280 citations.
Papers
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Journal ArticleDOI
Biologically erodable microspheres as potential oral drug delivery systems
Edith Mathiowitz,Jules S. Jacob,Yong S. Jong,Gerardo Carino,Donald E. Chickering,Pravin Chaturvedi,Camilla A. Santos,Kavita Vijayaraghavan,Sean Montgomery,Michael J Bassett,Craig N. Morrell +10 more
TL;DR: It is shown that engineered polymer microspheres made of biologically erodable polymers, which display strong adhesive interactions with gastrointestinal mucus and cellular linings, can traverse both the mucosal absorptive epithelium and the follicle-associated epithelia covering the lymphoid tissue of Peyer's patches.
Patent
Process for preparing microparticles through phase inversion phenomena
TL;DR: In this paper, a process for preparing nanoparticles and microparticles is described, which involves forming a mixture of a polymer and a solvent, wherein the solvent is present in a continuous phase and introducing the mixture into an effective amount of a nonsolvent to cause the spontaneous formation of micro particles.
Patent
Polymeric gene delivery system
TL;DR: In this paper, a means for obtaining efficient introduction of exogenous genes into a patient, with long term expression of the gene, is disclosed, under control of an appropriate promoter for expression in a particular cell type, is encapsulated or dispersed with a biocompatible, preferably biodegradable polymeric matrix, where the gene is able to diffuse out of the matrix over an extended period of time.
Patent
Polymeric gene delivery
TL;DR: In this article, a means for obtaining efficient introduction of exogenous genes into a patient, with long term expression of the gene, is disclosed, under control of an appropriate promoter for expression in a particular cell type, is encapsulated or dispersed with a biocompatible, preferably biodegradable polymeric matrix, where the gene is able to diffuse out of the matrix over an extended period of time.
Journal Article
In situ tumor vaccination with interleukin-12-encapsulated biodegradable microspheres: induction of tumor regression and potent antitumor immunity.
Nejat K. Egilmez,Yong S. Jong,Michael S. Sabel,Jules S. Jacob,Edith Mathiowitz,Richard B. Bankert +5 more
TL;DR: The utility of biodegradable polymer microspheres as a clinically feasible alternative to systemic cytokine therapy and cytokine gene-modified cell vaccines for the treatment of neoplastic disease is established.