C
Camilla A. Santos
Researcher at Brown University
Publications - 10
Citations - 1224
Camilla A. Santos is an academic researcher from Brown University. The author has contributed to research in topics: Drug delivery & Bioadhesive. The author has an hindex of 9, co-authored 10 publications receiving 1198 citations.
Papers
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Journal ArticleDOI
Biologically erodable microspheres as potential oral drug delivery systems
Edith Mathiowitz,Jules S. Jacob,Yong S. Jong,Gerardo Carino,Donald E. Chickering,Pravin Chaturvedi,Camilla A. Santos,Kavita Vijayaraghavan,Sean Montgomery,Michael J Bassett,Craig N. Morrell +10 more
TL;DR: It is shown that engineered polymer microspheres made of biologically erodable polymers, which display strong adhesive interactions with gastrointestinal mucus and cellular linings, can traverse both the mucosal absorptive epithelium and the follicle-associated epithelia covering the lymphoid tissue of Peyer's patches.
Patent
Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
TL;DR: Anhydride oligomers can be incorporated within polymers used to form or coat drug delivery systems, such as microspheres which contain a drug or diagnostic agent as mentioned in this paper, which can be either solubilized and blended with the polymer before manufacture or else used as a coating with polymers over existing systems.
Journal ArticleDOI
Correlation of two bioadhesion assays: the everted sac technique and the CAHN microbalance.
Camilla A. Santos,Jules S. Jacob,Benjamin A. Hertzog,B.D Freedman,D.L Press,P Harnpicharnchai,Edith Mathiowitz +6 more
TL;DR: It is demonstrated that CAHN and everted sac experiments yield similar results when used to quantify the bioadhesive nature of polymer microsphere systems.
Journal ArticleDOI
Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model.
Nejat K. Egilmez,Yong S. Jong,Yoshimi Iwanuma,Jules S. Jacob,Camilla A. Santos,Fang-An Chen,Edith Mathiowitz,Richard B. Bankert +7 more
TL;DR: This is the first evidence that the rejection of human tumor xenografts can be provoked by the sustained in vivo delivery of IL-2 from biodegradable microspheres.
Journal ArticleDOI
Poly(fumaric–co-sebacic anhydride): A degradation study as evaluated by FTIR, DSC, GPC and X-ray diffraction
TL;DR: It is demonstrated that degradation of P(FA:SA) is greatly accelerated at basic pH, yet there is little difference between degradation in neutral and acidic buffers.