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Yong-Xiang Chen
Researcher at Libin Cardiovascular Institute of Alberta
Publications - 50
Citations - 1210
Yong-Xiang Chen is an academic researcher from Libin Cardiovascular Institute of Alberta. The author has contributed to research in topics: Heat shock protein & Inflammation. The author has an hindex of 20, co-authored 47 publications receiving 1059 citations. Previous affiliations of Yong-Xiang Chen include University of Calgary & University of Ottawa.
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Journal ArticleDOI
The evolution of coronary stents: a brief review.
Trevor Simard,Benjamin Hibbert,F. Daniel Ramirez,Michael Froeschl,Yong-Xiang Chen,Edward R. O'Brien,Edward R. O'Brien +6 more
TL;DR: Although DESs have incrementally improved outcomes after percutaneous coronary intervention, delayed re-endothelialization and stent thrombosis remain important challenges.
Journal ArticleDOI
Extracellular Release of the Atheroprotective Heat Shock Protein 27 Is Mediated by Estrogen and Competitively Inhibits acLDL Binding to Scavenger Receptor-A
Katey J. Rayner,Yong-Xiang Chen,Melissa McNulty,Trevor Simard,Xioaling Zhao,Dominic J. Wells,Jacqueline de Belleroche,Edward R. O'Brien +7 more
TL;DR: HSP27 is atheroprotective, perhaps because of its ability to compete for the uptake of atherogenic lipids or attenuate inflammation in macrophages treated with estrogen or acLDL.
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Modulation of Estrogen Signaling by the Novel Interaction of Heat Shock Protein 27, a Biomarker for Atherosclerosis, and Estrogen Receptor β
Harvey Miller,Stephanie Poon,Benjamin Hibbert,Katey J. Rayner,Yong-Xiang Chen,Edward R. O'Brien +5 more
TL;DR: HSP27, an ER&bgr;-associated protein, shows attenuated expression with coronary atherosclerosis and modulates estrogen signaling.
Journal ArticleDOI
Heat Shock Protein 27 Protects Against Atherogenesis via an Estrogen-Dependent Mechanism. Role of Selective Estrogen Receptor Beta Modulation
Katey J. Rayner,Jiangfeng Sun,Yong-Xiang Chen,Melissa McNulty,Trevor Simard,Xiaoling Zhao,Dominic J. Wells,Jacqueline de Belleroche,Edward R. O'Brien +8 more
TL;DR: Whether estrogens are required for the observed atheroprotective benefits of HSP27 as well as its extracellular release and atheroprotection is estrogen dependent.
Journal ArticleDOI
Cardiac ryanodine receptor calcium release deficiency syndrome
Bo Sun,Bo Sun,Jinjing Yao,Mingke Ni,Jinhong Wei,Xiaowei Zhong,Wenting Guo,Lin Zhang,Ruiwu Wang,Darrell D. Belke,Yong-Xiang Chen,Krystien V.V. Lieve,Anders Krogh Broendberg,Thomas M. Roston,Ivan Blankoff,Janneke A.E. Kammeraad,Johannes C. von Alvensleben,Julieta Lazarte,Alexander Vallmitjana,Loryn J. Bohne,Robert A. Rose,Raul Benitez,Leif Hove-Madsen,Carlo Napolitano,Robert A. Hegele,Michael Fill,Shubhayan Sanatani,Arthur A.M. Wilde,Jason D. Roberts,Silvia G. Priori,Henrik Jensen,S. R. Wayne Chen,S. R. Wayne Chen +32 more
TL;DR: In this article, the authors performed clinical and genetic evaluations of individuals who suffered from sudden cardiac death (SCD) and harbored an LOF RyR2 mutation, which can be reproduced on exercise stress testing (EST).